Age-stratified risk of unexpected uterine sarcoma following surgery for presumed benign leiomyoma

The Oncologist
Andrew S BrohlRobert G Maki

Abstract

Estimates of unexpected uterine sarcoma following surgery for presumed benign leiomyoma that use age-stratification are lacking. A retrospective cohort of 2,075 patients that had undergone myomectomy was evaluated to determine the case incidence of unexpected uterine sarcoma. An aggregate risk estimate was generated using a meta-analysis of similar studies plus our data. Database-derived age distributions of the incidence rates of uterine sarcoma and uterine leiomyoma surgery were used to stratify risk by age. Of 2,075 patients in our retrospective cohort, 6 were diagnosed with uterine sarcoma. Our meta-analysis revealed 8 studies from 1980 to 2014. Combined with our study, 18 cases of leiomyosarcoma are reported in 10,120 patients, for an aggregate risk of 1.78 per 1,000 (95% confidence interval [CI]: 1.1-2.8) or 1 in 562. Eight cases of other uterine sarcomas were reported in 6,889 patients, for an aggregate risk of 1.16 per 1,000 (95% CI: 0.5-4.9) or 1 in 861. The summation of these risks gives an overall risk of uterine sarcoma of 2.94 per 1,000 (95% CI: 1.8-4.1) or 1 in 340. After stratification by age, we predict the risk of uterine sarcoma to range from a peak of 10.1 cases per 1,000, or 1 in 98, for patients aged 75-79 ...Continue Reading

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Citations

Jan 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jiaren ZhangJinhua Leng
Dec 25, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ana M RodriguezGokhan S Kilic
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Jul 16, 2021·Journal of Minimally Invasive Gynecology·Rosanne M KhoXiao Xu

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