Age Threshold for Ischemic Stroke Risk in Atrial Fibrillation

Stroke; a Journal of Cerebral Circulation
Tae-Hoon KimGregory Yh Lip

Abstract

Background and Purpose- Although older age is one of the most important risk factor for stroke in atrial fibrillation (AF), the appropriate age threshold (eg, CHA2DS2-VASc score [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65-74 years, female], 1 point for age 65-74 years, 2 points for age ≥75 years) for increased risk is controversial because actual age thresholds may differ between countries and ethnic groups. We investigated the age threshold for ischemic stroke risk among Asian AF patients. Methods- Using National Health Insurance Service database, including 426 650 oral anticoagulant-naive nonvalvular AF patients from 2005 to 2015, with ≤2 nongender-related CHA2DS2-VASc risk scores (CHA2DS2-VASc score 0-2 in males, 1-3 in females), we assessed the risk of ischemic stroke in AF patients according to the age. Results- Patients who fulfill the age risk criterion (age, 65-74 years) without other risk factors showed a significantly higher risk of stroke (4.76 per 100 person-years [100PY]; adjusted hazard ratio, 2.25; 95% confidence interval [CI], 2.17-2.36) compared with patients with 1 risk score other than age (1...Continue Reading

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Citations

Jul 18, 2018·Stroke; a Journal of Cerebral Circulation·Lars Frost, Søren Paaske Johnsen
Nov 16, 2019·Clinical Cardiology·Yun Gi KimYoung-Hoon Kim
Aug 12, 2020·Journal of the American Heart Association·Sun Young ChoiGregory Y H Lip
Nov 8, 2018·Korean Circulation Journal·Boyoung JoungUNKNOWN KHRS Atrial Fibrillation Guideline Working Group
Aug 29, 2019·Korean Circulation Journal·Boyoung Joung
Nov 6, 2020·International Journal of Cardiology·Tommy Andersson, Sara Aspberg
Jan 1, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Tze-Fan ChaoTatjana S Potpara
Jan 1, 2021·European Heart Journal Supplements : Journal of the European Society of Cardiology·Deirdre A Lane, Gregory Y H Lip
Apr 26, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan SteffelUNKNOWN External reviewers
Jul 7, 2021·Korean Circulation Journal·Ling KuoTze Fan Chao

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