Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective Randomized Double-Blind Study

The Journal of Nutrition
Suguru MatsumotoMatthew Budoff

Abstract

Although several previous studies have demonstrated that aged garlic extract (AGE) inhibits the progression of coronary artery calcification, its effect on noncalcified plaque (NCP) has been unclear. This study investigated whether AGE reduces coronary plaque volume measured by cardiac computed tomography angiography (CCTA) in patients with metabolic syndrome (MetS). Fifty-five patients with MetS (mean ± SD age: 58.7 ± 6.7 y; 71% men) were prospectively assigned to consume 2400 mg AGE/d (27 patients) or placebo (28 patients) orally. Both groups underwent CCTA at baseline and follow-up 354 ± 41 d apart. Coronary plaque volume, including total plaque volume (TPV), dense calcium (DC), NCP, and low-attenuation plaque (LAP), were measured based upon predefined intensity cutoff values. Multivariable linear regression analysis, adjusted for age, gender, number of risk factors, hyperlipidemia medications, history of coronary artery disease, scan interval time, and baseline %TPV, was performed to examine whether AGE affected each plaque change. The %LAP change was significantly reduced in the AGE group compared with the placebo group (-1.5% ± 2.3% compared with 0.2% ± 2.0%, P = 0.0049). In contrast, no difference was observed in %TPV ch...Continue Reading

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References

Oct 7, 2000·Clinical and Experimental Pharmacology & Physiology·S Kim-Park, D D Ku
Mar 27, 2001·Archives of Internal Medicine·R T AckermannV A Lawrence
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Feb 18, 2006·The Journal of Nutrition·Khalid Rahman, Gordon M Lowe
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Sadako MotoyamaJagat Narula
Mar 11, 2009·Journal of Cardiovascular Computed Tomography·Gilbert L RaffUNKNOWN Society of Cardiovascular Computed Tomography
Jun 27, 2009·Journal of the American College of Cardiology·Sadako MotoyamaJagat Narula
Sep 8, 2010·The International Journal of Cardiovascular Imaging·Maiken Glud DalagerHans Erik Bøtker
Jan 21, 2011·The New England Journal of Medicine·Gregg W StoneUNKNOWN PROSPECT Investigators
Apr 27, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gary S MintzPatrick W Serruys
Mar 21, 2012·JACC. Cardiovascular Imaging·Stella-Lida PapadopoulouPim J de Feyter
Dec 18, 2012·European Heart Journal·Erling FalkRenu Virmani
Feb 26, 2013·The New England Journal of Medicine·Ramón EstruchUNKNOWN PREDIMED Study Investigators
Oct 24, 2013·Journal of Cardiovascular Computed Tomography·Song Shou MaoMatthew J Budoff

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Citations

Oct 22, 2016·Journal of Natural Medicines·Naoaki Morihara, Atsuko Hino
Jan 24, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chiara MameliCristiana Perrotta
Jun 5, 2018·Expert Review of Cardiovascular Therapy·Chandana Shekar, Matthew Budoff
Jul 12, 2019·Phytotherapy Research : PTR·Christian VlachojannisSigrun Chrubasik-Hausmann
Nov 27, 2019·Journal of Clinical Medicine·Amir TajbakhshAmirhossein Sahebkar
Jan 12, 2020·Current Hypertension Reports·Isabel QuesadaClaudia Castro
Sep 7, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Minhal Alhashim, Jamie Lombardo
Feb 6, 2020·Experimental and Therapeutic Medicine·Masahiro Ohtani, Tsubasa Nishimura
Feb 6, 2020·Experimental and Therapeutic Medicine·Hailong SongZezong Gu
May 29, 2018·Current Cardiology Reports·Vanessa BianconiMatteo Pirro
Apr 21, 2020·The International Journal of Cardiovascular Imaging·Suvasini LakshmananMatthew J Budoff
Apr 30, 2020·The American Journal of Chinese Medicine·Muhammad NaveedLi Changxing
Sep 17, 2020·Nutrients·Francesc Josep García-GarcíaGlòria Garrabou
Mar 27, 2021·Archives of Physiology and Biochemistry·Victor Udo NnaChukwuemeka Nwokocha
Jul 31, 2021·Journal of Cardiovascular Computed Tomography·Michelle C WilliamsHarvey Hecht

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