Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice

The Journal of Nutrition
Naoaki MoriharaJun-Ichiro Suzuki

Abstract

Aged garlic extract (AGE) has been shown to retard the progression of coronary calcification in patients with coronary artery disease. To clarify the mechanism of AGE's action to retard atherosclerosis, we investigated whether AGE suppresses the formation and progression of atherosclerosis in Apolipoprotein E (Apoe)-knockout (ApoE-KO) mice. Male C57BL/6J mice (control mice, 5 wk old) were fed a standard diet, whereas male ApoE-KO mice (5 wk old) were fed a standard diet with or without 3% AGE for 12 or 24 wk. After the treatment, blood samples, aortas, and spleens were collected from all mice. Concentrations of total cholesterol (TC), HDL cholesterol, and triglycerides (TGs) in serum were measured. The area of atherosclerotic lesion in the aorta was examined by Oil Red O staining. The relative abundances of monocytes plus macrophages (CD11b(+) cells) and interferon-γ-producing CD4(+) T cells in spleen were assessed by flow cytometric analysis. The atherosclerotic lesion areas in the aortas of ApoE-KO mice were 87 and 114 times as great (P < 0.01) as those in control mice at 12 and 24 wk, respectively. AGE feeding significantly inhibited the progression of atherosclerotic lesion area in ApoE-KO mice by 22% (P < 0.05) at 12 wk. I...Continue Reading

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Citations

Dec 31, 2010·The Journal of Nutritional Biochemistry·Patricia RojasElizabeth Ruiz-Sánchez
Mar 19, 2005·Burns : Journal of the International Society for Burn Injuries·D AgayY Chancerelle
Oct 22, 2016·Journal of Natural Medicines·Naoaki Morihara, Atsuko Hino
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Sep 29, 2021·CNS & Neurological Disorders Drug Targets·Ramin Ahangar-SirousNiloofar Deravi

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