PMID: 15383582Sep 24, 2004Paper

Aged mice develop protective antitumor immune responses with appropriate costimulation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Joseph LustgartenMarilyn Thoman

Abstract

There is a clear decrease in CD8(+) T cell effector function with aging, a loss once thought to be intrinsic to the CD8(+) T cells. Recent studies suggest, however, that this decline may be a consequence of altered stimulatory signals within the aged lymphoid microenvironment. In this study, we compared the immune responses of young and old mice against the BM-185 pre-B cell lymphoma expressing enhanced GFP (EGFP) as a surrogate tumor Ag. Young animals develop protective immune responses when immunized with BM-185-EGFP, but aged mice do not and ultimately succumb to the tumor. However, expression of CD80 (B7.1) on the BM-185-EGFP (BM-185-EGFP-CD80) results in rejection of the tumor by both young and old animals. Additionally, injection of BM-185-EGFP-CD80 cells in young mice promotes the development of long-lasting memory responses capable of rejecting BM-185 wild-type tumors. Aged animals similarly injected did not develop antitumor memory responses. Interestingly, old animals immunized with the BM-185-EGFP-CD80 cells plus injections of the agonist anti-OX40 mAb did develop long-lasting memory responses capable of rejecting the BM-185 wild-type tumors with the same vigor as the young animals. We show that old mice have the cap...Continue Reading

References

Jul 1, 1993·Experimental Gerontology·L SongW H Adler
Nov 1, 1996·The Journal of Experimental Medicine·P J LintonS L Swain
Feb 26, 1998·Immunological Reviews·C C KuP Marrack
Aug 28, 1998·Mechanisms of Ageing and Development·R Solana, G Pawelec
Apr 7, 1999·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·X Y Mu, M L Thoman
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A D WeinbergJ Shields
Sep 28, 2000·Current Opinion in Immunology·A A HurwitzA van Elsas
Mar 17, 2001·Archives of Gerontology and Geriatrics·L MalaguarneraA Messina
Jun 8, 2001·Mechanisms of Ageing and Development·C Gravekamp
Jun 21, 2001·Cellular Immunology·A R WeatherillA T Vella
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y MorelR T Costello
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thibaut De SmedtCharles Maliszewski
Feb 14, 2002·The British Journal of Dermatology·M BhushanC E M Griffiths
Jun 5, 2002·Mechanisms of Ageing and Development·Koichi UyemuraTakashi Makinodan
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaokang P LiPhyllis-Jean Linton
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiley R PrillimanStephen P Schoenberger
Feb 21, 2003·Nature·Edith M JanssenStephen P Schoenberger
Apr 12, 2003·Science·Joseph C Sun, Michael J Bevan
Sep 17, 2003·Nature Reviews. Immunology·Olivera J Finn

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Citations

May 12, 2009·Immunological Reviews·Michael CroftPejman Soroosh
Apr 14, 2012·Journal of Biomedicine & Biotechnology·Daria CapeceEdoardo Alesse
Nov 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sujin LeeMartin L Moore
Mar 13, 2015·Frontiers in Oncology·Stefanie N LinchWilliam L Redmond
Oct 1, 2016·Clinical and Experimental Immunology·V HurezT J Curiel
Jul 15, 2017·Drugs & Aging·Kate PoropatichBin Zhang
Jan 4, 2007·The Journal of Pathology·A L GruverG D Sempowski
Mar 17, 2009·Cancer Immunology, Immunotherapy : CII·Carl E Ruby, Andrew D Weinberg
Feb 25, 2009·Cancer Immunology, Immunotherapy : CII·Joseph Lustgarten
Mar 17, 2018·Frontiers in Cell and Developmental Biology·Mark OwyongVicki Plaks
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay SharmaJoseph Lustgarten
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carl E Ruby, Andrew D Weinberg
Sep 11, 2007·Cancer Immunology, Immunotherapy : CII·Sanjay SharmaJoseph Lustgarten
Mar 5, 2009·Cancer Immunology, Immunotherapy : CII·Claudia Gravekamp
Apr 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noweeda MirzaJoseph Lustgarten
Feb 10, 2009·Cancer Immunology, Immunotherapy : CII·Mauro Provinciali
Feb 13, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mei-Chuan HuangEdward J Goetzl
Sep 17, 2011·Cancer Immunology, Immunotherapy : CII·Mauro ProvincialiArianna Smorlesi
Nov 11, 2020·ELife·Jefte M DrijversMarcia C Haigis
Jul 3, 2008·Cancer Research·Ana Lucia Dominguez, Joseph Lustgarten
Mar 15, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karin SchreiberHans Schreiber
Oct 11, 2017·Experimental Gerontology·Vincent HurezTyler J Curiel

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