PMID: 11311318Apr 20, 2001Paper

Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells

Mechanisms of Ageing and Development
H C HsuJohn D Mountz

Abstract

We previously reported that T cells from aged mice were resistant to activation-induced cell death (AICD) in vitro. To determine whether the presence of AICD-resistant T cells is associated with defects in age-related peripheral clonal deletion in vivo, congenic male SCID mice were reconstituted with T cells from aged or young female D(b)/H-Y TCR (Tg71) transgenic mice. Compared with recipients of young cells, the recipients of T cells from aged mice exhibited a 3-fold increase in the percentage of autoreactive CD8(+) H-Y antigen-reactive T cells as defined by the clonotypic antibody, M33. There were significantly increased sera levels of interferon-gamma, a significantly decreased expression of FasL by M33(+)CD8(+) T cells, and significantly decreased apoptosis by DNA fragmentation staining of the spleen of mice reconstituted with T cells from aged mice compared to those from young mice. By day 21, the recipients of T cells from aged mice but not young mice, exhibited infiltration of CD3(+) cells into the non-lymphoid organs. These results indicate that there is defective peripheral deletion of the self-reactive T cells derived from aged female Tg71 mice, and that failure to delete these cells is associated with the defective ...Continue Reading

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Citations

Sep 15, 2001·Mechanisms of Ageing and Development·H C HsuJ D Mountz
Jun 5, 2002·Mechanisms of Ageing and Development·John D MountzHui-Chen Hsu
Jun 5, 2002·Mechanisms of Ageing and Development·Sue StacyEllen Kraig
Dec 1, 2010·Immunity & Ageing : I & a·Yazdani B Shaik-DasthagirisahebFrank C Gibson
May 11, 2005·Immunological Reviews·Hui-Chen HsuJohn D Mountz
Oct 10, 2006·Artificial Organs·Miriam CapriClaudio Franceschi
Jul 28, 2007·Current Opinion in Immunology·Sue J SohnAstar Winoto
Nov 18, 2011·Toxicologic Pathology·George A Parker, Catherine A Picut
Jun 20, 2002·The Journal of Biological Chemistry·Kate J ClaycombeSimin Nikbin Meydani
Mar 29, 2002·Nature Immunology·Hartmut Geiger, Gary Van Zant

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