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Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease

Scientific Reports

Oct 31, 2019

Athanasios MetaxasBente Finsen

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Abstract

Despite compelling evidence that the accumulation of amyloid-beta (Aβ) promotes neocortical MAPT (tau) aggregation in familial and idiopathic Alzheimer's disease (AD), murine models of cerebral amyloidosis are not considered to develop tau-associated pathology. In the present study, we ...read more

Mentioned in this Paper

Alzheimer's Disease
Amyloidosis
Brain
Energy Metabolism
Laboratory mice
Mice, Transgenic
Electron Microscopy
Pathology
RNA
Tau Proteins
1
1
9
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Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease

Scientific Reports

Oct 31, 2019

Athanasios MetaxasBente Finsen

PMID: 31673052

DOI: 10.1038/s41598-019-52357-5

Abstract

Despite compelling evidence that the accumulation of amyloid-beta (Aβ) promotes neocortical MAPT (tau) aggregation in familial and idiopathic Alzheimer's disease (AD), murine models of cerebral amyloidosis are not considered to develop tau-associated pathology. In the present study, we ...read more

Mentioned in this Paper

Alzheimer's Disease
Amyloidosis
Brain
Energy Metabolism
Laboratory mice
1
1
9

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