Ageing and cancer as diseases of epigenesis.

Journal of Biosciences
Scott F Gilbert

Abstract

Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome. However, as we have learned more about the expression of the genome, we find that differences in expression can be as important as differences in alleles. It is easier to inactivate a gene by methylation than by mutation, and given that appropriate methylation is essential for normal development, one can immediately see that diseases would result as a consequence of inappropriate epigenetic methylation. While first proposed by Boris Vanyushin in 1973, recent studies have confirmed that inappropriate methylation not only causes diseases, and it also may be the critical factor in ageing and cancers.

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Citations

Feb 4, 2011·Journal of Biosciences·Min LiXinyu Qin
Aug 23, 2011·Journal of Biosciences·Wing-Fu Lai
Feb 16, 2013·Social Work·Terri Combs-Orme
Mar 13, 2012·World Journal of Gastroenterology : WJG·Xiang-Quan LiWei De
Dec 17, 2015·Expert Opinion on Therapeutic Targets·Sajid KhanSyed Musthapa Meeran
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Jul 19, 2019·Mycologia·Piotr BorońTadeusz Kowalski
Jan 9, 2015·The Journal of Experimental Biology·Qihua TanKaare Christensen

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