Ageing and circadian rhythm of plasma renin and aldosterone

Maturitas
P CuginiF Massimiani

Abstract

Five men and 8 women, 60-69 yr of age, and 4 men and 5 women, 17-37 yr of age, volunteered for this exploration of possible age-related changes in circadian-rhythm (CR) characteristics of radioimmunoassayable plasma renin (PRA) and aldosterone (PA). Blood was drawn at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 from recumbent subjects on a habitual sodium intake of 120-140 mEq/24 h. Time-qualified data of PRA and PA, fitted by a 24-h cosine curve, were summarized by a population mean-cosinor method. Circadian characteristics were compared by a multivariate analysis using Hotelling's t2 test. Rhythmometry reveals in the elderly women a lower mesor (P less than 0.001) and amplitude (P = 0.036) of the CR in PRA and a higher mesor and amplitude (P = 0.021 and P = 0.020, respectively) of the PA-CR. The PRA acrophase is delayed (P less than 0.001) in the elderly women (04.40 vs. 08.04) while the timing of the PA acrophase is similar in the age groups of women compared (05.52 vs. 05.20). These differences found in women were not observed in the smaller groups of men. The seventh decade of life may be characterized by an internal circadian desynchronization between the major components of the renin-angiotensin-aldosterone system. A sex...Continue Reading

References

Apr 3, 1980·The New England Journal of Medicine·J Brachfeld
Aug 1, 1962·The Journal of Clinical Investigation·J R BLAIR-WESTM WINTOUR

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Citations

Apr 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P CuginiA Cianetti
Apr 1, 1985·General and Comparative Endocrinology·Y OkawaraH Kobayashi
Oct 1, 1984·Biochemical Medicine·P CuginiG Cornelissen
Jun 1, 1983·Maturitas·A HodgkinsonA W Burrows
Jan 1, 1991·Journal of the American Geriatrics Society·M A Brock
Feb 27, 2019·Journal of Veterinary Internal Medicine·Marisa K AmesBertram Pitt
Jul 4, 2020·Chronobiology International·Germaine CornelissenKuniaki Otsuka
Feb 1, 1983·Journal of Endocrinological Investigation·P CuginiT Kawasaky
May 7, 2021·Chronobiology International·Germaine CornelissenKuniaki Otsuka

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