Ageing and testicular function in Octodon degus

Andrologia
E B Obregón, O Ramirez

Abstract

The present study analyses cell loss and proliferation which account for the decrease in the number of germ cell populations in the senile male Octodon degus. This is a good model to study ageing in wild animals, since it has recently been incorporated as a laboratory animal but still has a high degree of genetic heterogeneity, thus representing a situation found in natural systems. The cell loss from pachytene spermatocytes to round spermatids is estimated by cell counts in the cross section of seminiferous tubules. DNA testicular synthesis is measured by scintillation counting and the index of labelling of spermatogonia by radioautography of testes comparing sexually mature young animals and senile animals. Other determinations in both groups are testis weight, thickness of the albuginea and tubular wall, daily sperm production, percentage of depleted seminiferous tubules and nuclear cell diameters of germ cells. The results suggest a decrease in the number of cell population in the senile animals resulting from an increase in physiological cell loss coupled with a decreased proliferative spermatogonial activity. There is also a decreased yield of meiosis in terms of round spermatid production. Lowered testosterone levels bot...Continue Reading

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Citations

May 28, 2015·Journal of Evolutionary Biology·R C FirmanC Gasparini
May 5, 2017·The Journal of Comparative Neurology·Simon M LauerMichael Brecht
Apr 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joana SantiagoMargarida Fardilha
Jun 2, 2009·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Mauricio Soto-GamboaLuis A Ebensperger

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