Ageing changes in biventricular cardiac function in male and female baboons (Papio spp.)

The Journal of Physiology
Anderson H KuoGeoffrey D Clarke

Abstract

Life course changes in cardiovascular function in a non-human primate have been comprehensively characterized. Age-related declines in normalized left ventricular stroke volume and cardiac output were found with corresponding decreases in biventricular ejection fractions and filling rates. There were age-related decreases in male and female baboon normalized left ventricular myocardial mass index, which declined at similar rates. Systolic functional declines in right ventricular function were observed with age, similar to the left ventricle. Sex differences were found in the rates and directions of right ventricular volume changes along with decreased end-systolic right ventricular sphericity. The results validate the baboon as an appropriate model for translational studies of cardiovascular functional decline with ageing. Previous studies reported cardiac function declines with ageing. This study determined changes in biventricular cardiac function in a well-characterized baboon model. Cardiac magnetic resonance imaging measured key biventricular parameters in 47 baboons (22 female, age 4-23 years). ANCOVA assessed sex and age changes with P < 0.05 deemed significant. Stroke volume, cardiac output and other cardiac functional ...Continue Reading

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Citations

Sep 22, 2018·The Journal of Physiology·Jack R T Darby, Janna L Morrison
Jan 5, 2019·Journal of Cellular Physiology·Peng XiaoXingwei Liang
Mar 20, 2021·Frontiers in Physiology·Kathleen C Woulfe, Lori A Walker
Oct 30, 2021·Comparative Medicine·Hillary F HuberGeoffrey D Clarke

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