Ageing diminishes the modulation of human brain responses to visual food cues by meal ingestion

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Y S CheahS A Amiel

Abstract

Rates of obesity are greatest in middle age. Obesity is associated with altered activity of brain networks sensing food-related stimuli and internal signals of energy balance, which modulate eating behaviour. The impact of healthy mid-life ageing on these processes has not been characterised. We therefore aimed to investigate changes in brain responses to food cues, and the modulatory effect of meal ingestion on such evoked neural activity, from young adulthood to middle age. Twenty-four healthy, right-handed subjects, aged 19.5-52.6 years, were studied on separate days after an overnight fast, randomly receiving 50 ml water or 554 kcal mixed meal before functional brain magnetic resonance imaging while viewing visual food cues. Across the group, meal ingestion reduced food cue-evoked activity of amygdala, putamen, insula and thalamus, and increased activity in precuneus and bilateral parietal cortex. Corrected for body mass index, ageing was associated with decreasing food cue-evoked activation of right dorsolateral prefrontal cortex (DLPFC) and precuneus, and increasing activation of left ventrolateral prefrontal cortex (VLPFC), bilateral temporal lobe and posterior cingulate in the fasted state. Ageing was also positively as...Continue Reading

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Citations

Aug 5, 2016·Physiological Reviews·Stephanie KullmannHans-Ulrich Häring
Nov 17, 2020·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Christie BennettJudi Porter
Jan 27, 2020·Behavioural Brain Research·Céline CharroudPhilippe Coubes

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