Ageing effects on humoral immune responses in chronic periodontitis

Journal of Clinical Periodontology
J L EbersoleDolph R Dawson

Abstract

Periodontal disease is a dominant global bacterial infection that increases with ageing. This report focuses on host adaptive immune responses in periodontitis. While experimental models and humans diagnosed with periodontitis demonstrate an antigenic specificity for particular oral bacteria, we have a limited understanding of (i) how ageing affects the adaptive immune responses to these bacteria that chronically colonize the oral cavity for decades prior to disease expression and (ii) how the magnitude and specificity of the response interface with pathogens that emerge within the bacterial ecology during exacerbations of disease. Serum antibody levels to a group of pathogenic and commensal oral bacteria were measured in a population of individuals from 21 to 74 years of age, stratified based on clinical status of the periodontium, smoking and sex. Clinical parameters were not significantly different within health, gingivitis or periodontitis groups related to age. Antibody to oral pathogens and commensals was similar in different age groups in each of the clinical categories, with no age correlation noted in the periodontitis patients. The adaptive immune responses to oral bacteria that chronically colonize the oral cavity ap...Continue Reading

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Citations

Aug 28, 2019·Experimental and Therapeutic Medicine·Weijuan QiBuling Wu
Dec 18, 2018·Current Oral Health Reports·J L EbersoleO A Gonzalez
Apr 9, 2021·Frontiers in Cellular and Infection Microbiology·Magdalena LenartovaLucie Najmanova
Jun 3, 2021·International Journal of Environmental Research and Public Health·Patrícia LyraJoão Botelho

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