Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial.

Interactive Cardiovascular and Thoracic Surgery
Ramón RodrigoPablo Guzmán

Abstract

Extracorporeal circulation is associated with ischaemia-reperfusion-induced oxidative stress and atrial fibrillation (AF). Ageing is the major risk factor for this arrhythmia. Reinforcing the antioxidant defence system would be expected to protect the myocardium against ischaemia-reperfusion damage. We studied the effect of antioxidant reinforcement and ageing on the occurrence of postoperative AF. A randomized, double-blind, placebo-controlled trial was performed in patients scheduled for cardiac surgery with extracorporeal circulation. Supplementation with omega-3 polyunsaturated fatty acid (PUFA) and vitamins C and E, or placebo was administered to 152 patients divided by age: young patients (30-59 years) and old patients (60-80 years). For the detection of AF, we used 12-lead and Holter EKGs. Antioxidant enzyme activity was determined in atrial tissue. Oxidative stress was assessed through plasma malondialdehyde levels. Supplemented patients over 60 years old showed higher glutathione peroxidase activity than control patients in the same age range. There was no difference between the supplemented and placebo groups in patients under 60 years old. The decrease in the incidence of postoperative AF in supplemented patients was...Continue Reading

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Citations

Apr 8, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Francesco VioliLorenzo Loffredo
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Aug 2, 2016·Advanced Pharmaceutical Bulletin·Evangelos PolymeropoulosIoannis Τoumpoulis
Jun 25, 2017·Interactive Cardiovascular and Thoracic Surgery·Jun GengZhenya Shen
Jul 14, 2018·Free Radical Research·Panagiotis KorantzopoulosTong Liu
Jul 20, 2017·Current Medicinal Chemistry·Alexios S AntonopoulosDimitris Tousoulis
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Rossella D'OriaFrancesco Giorgino

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