Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage.

Free Radical Biology & Medicine
Brian McDonaghMalcolm J Jackson

Abstract

Ageing is associated with loss of skeletal muscle fibres, atrophy of the remaining fibres and weakness. These changes in muscle are accompanied by disruption of motor neurons and neuromuscular junctions although the direct relationship between the nerve and muscle degeneration is not understood. Oxidative changes have been implicated in the mechanisms leading to age-related loss of muscle mass and in degeneration of the central nervous system, but little is known about age-related changes in oxidation in specific peripheral nerves that supply muscles that are affected by ageing. We have therefore examined the sciatic nerve of old mice at an age when loss of tibialis anterior muscle mass and function is apparent. Sciatic nerve from old mice did not show a gross increase in oxidative damage, but electron paramagnetic resonance (EPR) studies indicated an increase in the activity of superoxide and/or peroxynitrite in the nerves of old mice at rest that was further exacerbated by electrical stimulation of the nerve to activate muscle contractions. Proteomic analyses indicated that specific redox-sensitive proteins are increased in content in the nerves of old mice that may reflect an adaptation to regulate the increased superoxide/p...Continue Reading

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Citations

May 25, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Katarzyna Goljanek-WhysallBrian McDonagh
Jul 27, 2017·Journal of Cachexia, Sarcopenia and Muscle·Giorgos K SakellariouBrian McDonagh
Feb 2, 2017·European Journal of Anaesthesiology·Jean-Pierre Estebe, Arthur Atchabahian
Jan 29, 2019·Frontiers in Physiology·Paul M CoenBenjamin F Miller
Aug 27, 2019·Redox Biology·Mattia ScalabrinAphrodite Vasilaki
Aug 28, 2021·International Journal of Molecular Sciences·Nicholas A ForemanLi Li Ji

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Methods Mentioned

BETA
dissection
electron paramagnetic resonance
acetylation
ubiquitination

Software Mentioned

Proteome Discoverer
Proteome Discovery
Mascot
[UNK]
AxioVision LE

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