PMID: 7715May 1, 1976

Ageing of Neurospora crassa. IV. Induction of senescence in wild type by dietary amino acid analogs and reversal by antioxidants and membrane stabilizers

Mechanisms of Ageing and Development
K D Munkres

Abstract

The extensional growth rate of wild-type 74A8 N. crassa in the presence of various concentrations of 19 amino acid analogs was measured. Seven analogs were not inhibitory at concentrations in the range of one to 10mM. Of the remaining 12 analogs, nine inhibited growth in a novel way. The kinetics of growth in the presence of these analogs at 30 degrees were characterized by seven sequential phases: (1)lag; (2) acceleration of growth rate; (3) steady-state growth rate; (4) exponential rate of decline of growth rate; (5) no growth or growth rate less than or equal to 0.1 mm h-1; (6) accleration of growth rate; and (7) steady state. At 33 degrees, phases 6 and 7 did not occur and irreparable death of the clones occurred. The mechanism by which the clones acquired resistance at 30 degrees appeared to involve a combination of physiological adaptation and cellular selection. Dietary application of either free radical scavengers or surface-active membrane 'stabilizers' alleviated or prevented the inhibition and deterioration of growth rate which occurred in the presence of the nine amino acid analogs. Culture with either 4-fluorophenylalanine or ethionine led to an increase of the activities of antioxygenic enzymes glutathione peroxid...Continue Reading

References

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Citations

Apr 1, 1978·Mechanisms of Ageing and Development·R S Rana, K D Munkres
Jan 1, 1988·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C Hammer, E Braum
Oct 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T Miyake, T Shibamoto
Sep 16, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T Miyake, T Shibamoto
Mar 12, 2003·Biochimie·Ji Eun ParkJeen-Woo Park
May 14, 2009·Vascular Health and Risk Management·Jacob George, Allan D Struthers
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Sep 26, 2002·Journal of Biochemistry and Molecular Biology·Seon Joo YoonJeen-Woo Park
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May 8, 2004·Free Radical Research·Joon-Hyuck YangJeen-Woo Park

Related Concepts

Adrenal Cortex Hormones
Antinociceptive Agents
Antioxidant Effect
Ethionine
Antihistamines, Classical
Neurospora
Neurospora crassa
4-Fluorophenylalanine
Vigilon
Irium

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