Agenesis of paranasal sinuses and nasal nitric oxide in primary ciliary dyskinesia

The European Respiratory Journal
M PifferiA L Boner

Abstract

Agenesis of paranasal sinuses has only been described in case reports of patients with primary ciliary dyskinesia (PCD). As agenesis of paranasal sinuses may contribute to low nasal nitric oxide levels, a common finding in PCD, we speculated that this condition might frequently occur in PCD patients. Patients referred for PCD evaluation were consecutively recruited for 30 months. In addition to standard diagnostic testing for PCD, a computed tomography (CT) scan of paranasal sinuses was performed in all subjects. 86 patients (46 children aged 8-17 yrs) were studied. PCD was diagnosed in 41 subjects and secondary ciliary dyskinesia (SCD) was diagnosed in the remaining 45 subjects. Frontal and/or sphenoidal sinuses were either aplastic or hypoplastic on CT scans in 30 (73%) out of 41 PCD patients, but in only 17 (38%) out of 45 with SCD (p = 0.002). There was a significant inverse correlation between the score for aplasia/hypoplasia of each paranasal sinus and nasal NO values in the PCD patients (p = 0.008, r = -0.432) but not in SCD (p = 0.07, r = -0.271). The findings of aplasia/hypoplasia of the frontal and or sphenoidal sinuses may be part of the spectrum of PCD and this finding should prompt exclusion of this condition.

Citations

Feb 26, 2004·American Journal of Respiratory and Critical Care Medicine·Wendy StannardChris O'Callaghan
Feb 11, 2014·BMC Pulmonary Medicine·Amanda HarrisJane S Lucas
Oct 23, 2013·Surgical and Radiologic Anatomy : SRA·B AnushaB Mohd Shaffie
Apr 29, 2014·Archives of Disease in Childhood·Jane S LucasUNKNOWN National PCD Service, UK
Jul 11, 2012·European Journal of Pediatrics·Mieke BoonKris De Boeck
Dec 25, 2013·Annals of the American Thoracic Society·Jane S Lucas, Woolf T Walker
Feb 24, 2016·Paediatric Respiratory Reviews·Lucy C Morgan, Catherine S Birman
Dec 15, 2015·Revue des maladies respiratoires·I Honoré, P-R Burgel
Mar 7, 2014·European Journal of Clinical Investigation·Mieke BoonKris De Boeck
Oct 21, 2016·Expert Review of Respiratory Medicine·Eleonora DehlinkAndrew Bush
Nov 24, 2016·International Forum of Allergy & Rhinology·Mikkel Christian AlaninChristian von Buchwald
Feb 9, 2018·The British Journal of Radiology·Tobias N AndersenSven Kreiborg
Nov 15, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Kazuhiko TakeuchiKaname Nakatani
Feb 11, 2016·World Journal of Clinical Pediatrics·Andrew Fretzayas, Maria Moustaki
Aug 27, 2014·Pediatric Pulmonology·Angelo MannaFrancesca Santamaria
Oct 18, 2014·The European Respiratory Journal·Samuel A CollinsJane S A Lucas
Jan 18, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Nisreen RummanJane S Lucas
May 10, 2019·Journal of Clinical Medicine·Emilie BequignonJean-François Papon
Jul 5, 2019·The Annals of Otology, Rhinology, and Laryngology·Sung Min HanDong-Joon Park
Jul 27, 2017·Expert Review of Respiratory Medicine·Jane S LucasWoolf T Walker
Oct 2, 2019·Translational Science of Rare Diseases·Margaret W LeighMichael R Knowles
Dec 14, 2011·Current Opinion in Allergy and Clinical Immunology·Raewyn Campbell
Jun 20, 2020·American Journal of Rhinology & Allergy·Andrew K PappaAdam J Kimple
May 9, 2019·Ear, Nose, & Throat Journal·Michael J MarinoEdward D McCoul
Sep 11, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jay M BhattKenny H Chan
Aug 29, 2018·Multidisciplinary Respiratory Medicine·Martina ContariniJames D Chalmers
Aug 28, 2020·Pediatric Investigation·Xiang ZhangShunying Zhao
Oct 15, 2013·Allergy & Rhinology·Hakan Korkmaz, Mukadder Korkmaz
May 23, 2020·Paediatric Respiratory Reviews·Claire Hogg, Andrew Bush
Jun 18, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Katherine DunskyThomas W Ferkol
Aug 30, 2021·Auris, Nasus, Larynx·Kazuki ChiyonobuKazuhiko Takeuchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.