PMID: 6536889Feb 1, 1984Paper

Agenesis of the corpus callosum in ddN strain mouse associated with unusual facial appearance (flat-face)

Neuroscience Research
H S OzakiM Shimada

Abstract

In the course of an experiment involving brother-sister matings between ddN strain mice, mice occurred with an unusual facial appearance (flat-face). Subsequently, 4 mice with flat-face were bred from the litters of the second birth (ca. 10% frequency). This flat-face was assumed to be the result of a malformed short nose, hypoplastic maxilla and mandible, and hypertelorism. These 4 flat-face mice exhibited no significant delays in growth, motor ability or the development of learning ability. Histologically, they were all characterized by an almost total absence of callosal fibers and the presence of abnormal longitudinal neuromatous bundles. Therefore, the flat-face mice may be useful as experimental animals for brain research, as one can easily judge that they lack the corpus callosum from the facial appearance.

Citations

Feb 18, 1994·Brain Research. Developmental Brain Research·D Wahlsten, B Bulman-Fleming
Oct 20, 1994·Behavioural Brain Research·D Wahlsten, P M Schalomon
Jun 1, 1992·The Japanese Journal of Psychiatry and Neurology·T UsukiK Hosokawa
Sep 26, 2009·Seminars in Pediatric Neurology·Amber-Lee S Donahoo, Linda J Richards
Aug 23, 1991·Brain Research·D Wahlsten, M Andison
Sep 1, 1992·The Journal of Comparative Neurology·H S Ozaki, D Wahlsten

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