Agenesis of the dorsal pancreas: a rare cause of insulin-dependent diabetes without abdominal pain: Case report

Medicine
Kaiyong LiangQunfang Lan

Abstract

Agenesis of the dorsal pancreas is a very rare condition with an unknown pathology and etiology, although it may be associated with autosomal dominant or X-linked dominant inheritance or retinoic acid and hedgehog signaling pathway alterations. This condition usually manifests with abdominal pain or pancreatitis, although some cases are asymptomatic. Approximately 50% of affected patients with this disorder present with hyperglycemia or various other anomalies. We report the case of a 23-year-old Chinese woman who visited the Department of Endocrinology and Metabolism with insulin-dependent diabetes but no specific symptoms, signs, or other deformities. Severe diabetic retinopathy indicated a long period of hyperglycemia. Agenesis of the dorsal pancreas was observed incidentally during the common diagnosis of diabetes, and the diagnosis was established using magnetic resonance imaging, diffusion-weighted imaging, and magnetic resonance cholangiopancreatography. Following the diagnosis of diabetes, insulin replacement therapy was initiated at a dosage of up to 45 U per day. The patient's blood glucose level was monitored, and the insulin dosage was adjusted accordingly. The patient's blood glucose levels gradually normalized aft...Continue Reading

References

Jul 12, 2008·Digestive Diseases and Sciences·Wolfgang J SchnedlHans E Hohmeier
Jan 14, 2009·World Journal of Gastroenterology : WJG·Wolfgang J SchnedlRainer W Lipp
Apr 23, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David W RittenhouseHarish Lavu
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Jul 16, 2014·The Indian Journal of Radiology & Imaging·Shruti ThakurCharu S Thakur

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Citations

Jun 6, 2019·Archives of Endocrinology and Metabolism·Cínthia Minatel RiguettoArnaldo Moura Neto
Apr 8, 2020·BMC Gastroenterology·Wentong MeiFei Li

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