Agent-Based Modeling in Systems Pharmacology

CPT: Pharmacometrics & Systems Pharmacology
J CosgroveM Coles

Abstract

Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.

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Sep 16, 2016·Journal of the Royal Society, Interface·Mark N ReadJon Timmis
Oct 6, 2017·Briefings in Bioinformatics·Xiaoqiang Sun, Bin Hu
Mar 3, 2018·Experimental & Molecular Medicine·Rolf ApweilerOlaf Wolkenhauer
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Jul 24, 2020·Nature Communications·Jason CosgroveMark C Coles
Dec 15, 2020·BMC Bioinformatics·Giulia RussoFrancesco Pappalardo
Feb 3, 2021·Mathematical Biosciences and Engineering : MBE·Kangbo Bao
Mar 18, 2021·Journal of the Royal Society, Interface·John T NardiniKevin B Flores
Feb 27, 2021·British Journal of Clinical Pharmacology·Mason McCombMurali Ramanathan
Mar 16, 2021·CPT: Pharmacometrics & Systems Pharmacology·Peter BloomingdaleSreeraj Macha
May 18, 2021·Frontiers in Bioengineering and Biotechnology·Matteo BelenchiaEmanuela Merelli

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

ARTIMMUS
EAE
MASON
JAVA
CoSMoS
PhysioLab
eFAST

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