Dec 30, 2015

Agent-based simulation of large tumors in 3-D microenvironments

BioRxiv : the Preprint Server for Biology
Ahmadreza GhaffarizadehPaul Macklin


Multicellular simulations of tumor growth in complex 3-D tissues, where data come from high content in vitro and bioengineered experiments, have gained significant attention by the cancer modeling community in recent years. Agent-based models are often selected for these problems because they can directly model and track cells' states and their interactions with the microenvironment. We describe PhysiCell, a specific agent-based model that includes cell motion, cell cycling, and cell volume changes. The model has been performance tested on systems of 10^5 cells on desktop computers, and is expected to scale to 10^6 or more cells on single super-computer compute nodes. We plan an open source release of the software in early 2016 at

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Mentioned in this Paper

Computer Software
Animal Cancer Model
Biomedical Engineering Field
Caveolin 3
Cell Cycle
Tumor Growth
In Vitro [Publication Type]
Anatomic Node

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