Agents in development for the management of cocaine abuse

Drugs
David GorelickZheng-Xiong Xi

Abstract

Cocaine abuse is a serious health problem in many areas of the world, yet there are no proven effective medications for the treatment of cocaine dependence. Preclinical studies suggest that the reinforcing effect of cocaine that promotes its abuse is mediated by blockade of the presynaptic dopamine transporter. This results in increased dopamine activity in the mesolimbic or meso-accumbens dopamine reward system of brain. Development of new medications to treat cocaine dependence has focused on manipulation of this dopamine system, either by direct action on dopamine binding sites (transporter or receptors) or indirectly by affecting other neurotransmitter systems that modulate the dopamine system. In principle, a medication could act via one of three mechanisms: (i) as a substitute for cocaine by producing similar dopamine effects; (ii) as a cocaine antagonist by blocking the binding of cocaine to the dopamine transporter; or (iii) as a modulator of cocaine effects by acting at other than the cocaine binding site. The US National Institute on Drug Abuse has a Clinical Research Efficacy Screening Trial (CREST) programme to rapidly screen existing medications. CREST identified four medications warranting phase II controlled clin...Continue Reading

References

Nov 1, 1987·The Journal of Nervous and Mental Disease·F R Schneier, S G Siris
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·K A Grant, C E Johanson
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·F J Vaccarino
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D GullyA Brouard
Jan 1, 1995·Journal of Addictive Diseases·P A ComptonD R Wesson
Feb 1, 1996·Current Opinion in Neurobiology·C E Henderson
Jan 1, 1996·Annual Review of Neuroscience·R A Wise
Mar 5, 1997·European Journal of Pharmacology·L PulvirentiG F Koob
May 1, 1997·Journal of Substance Abuse Treatment·D C OhuohaR B Rothman
Feb 4, 1998·Drug and Alcohol Dependence·D A Gorelick
Mar 12, 1998·Brain Research. Brain Research Reviews·P V Piazza, M Le Moal
Apr 16, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·W LingD Majewska
Apr 21, 1998·Biological Psychiatry·E F McCance-KatzP Jatlow
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·K Lee, C Kornetsky
Jul 22, 1998·Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques·R W Rockhold
Aug 26, 1998·Drug and Alcohol Dependence·H AkilS Watson
Jun 4, 1999·Journal of Clinical Pharmacology·L IavaroneG C Preston
Jun 15, 1999·Progress in Neurobiology·F Noble, B P Roques
Jul 23, 1999·Annals of the New York Academy of Sciences·T C Napier, I Mitrovic
Aug 7, 1999·Journal of Psychoactive Drugs·R MalcolmD Kajdasz

❮ Previous
Next ❯

Citations

Nov 9, 2007·Journal of Computer-aided Molecular Design·Fang Zheng, Chang-Guo Zhan
Jul 6, 2013·Progress in Neurobiology·Igor ElmanNora D Volkow
Mar 18, 2008·Journal of the American Chemical Society·Yongmei PanChang-Guo Zhan
May 1, 2009·The Journal of Physical Chemistry. B·Yongmei PanChang-Guo Zhan
May 13, 2009·Acta Pharmacologica Sinica·Zheng-xiong XiEliot L Gardner
Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark K GreenwaldCaren L Steinmiller
Nov 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Takato HiranitaJonathan L Katz
Apr 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A SlatteryJohn F Cryan
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zheng-Xiong XiEliot L Gardner
Oct 12, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark J Williams, Bryon Adinoff
Feb 16, 2011·Chemical Communications : Chem Comm·Saumen Hajra, Sukanta Bar
Mar 15, 2005·Harvard Review of Psychiatry·Bryon Adinoff
May 4, 2010·Protein Engineering, Design & Selection : PEDS·Diwahar NarasimhanRoger K Sunahara
Oct 17, 2009·Clinical Neuropharmacology·Stephen Ross, Eric Peselow
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Charles P O'Brien
Jun 9, 2006·Addiction Biology·John P DahlWade H Berrettini
May 19, 2007·Addiction Biology·Antonio Preti
May 12, 2010·Addiction Biology·Małgorzata FilipEdmund Przegaliński
Jun 30, 2012·Addiction Biology·Clara Velázquez-SánchezJuan J Canales
Jun 28, 2012·Addiction Biology·Giordano de GuglielmoRoberto Ciccocioppo
Jul 16, 2009·The Journal of Pharmacology and Experimental Therapeutics·Morgane ThomsenS Barak Caine
Aug 3, 2013·The Journal of Pharmacology and Experimental Therapeutics·Takato HiranitaJonathan L Katz
Nov 23, 2007·Journal of Addictive Diseases·Stanislay I SvetlovMark S Gold
Feb 4, 2012·Future Medicinal Chemistry·Craig R Rush, William W Stoops
Feb 4, 2012·Future Medicinal Chemistry·Fang Zheng, Chang-Guo Zhan
Feb 4, 2012·Future Medicinal Chemistry·Jia Bei Wang, John R Mantsch
Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yongmei PanChang-Guo Zhan
Nov 30, 2006·Journal of the American Chemical Society·Claude J RogersKim D Janda
May 17, 2006·Journal of Clinical Psychopharmacology·Jesse J SuhCharles P O'Brien
Jan 1, 2009·Expert Review of Clinical Pharmacology·Chang-Guo Zhan
Jun 15, 2005·Expert Opinion on Biological Therapy·Tobin J DickersonKim D Janda
Dec 18, 2010·Drug and Alcohol Dependence·P T HarrellD A Gorelick
Dec 10, 2014·Biomolecules & Therapeutics·Hye Jin ChaHo-Sang Jeong

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