AgeWell.de - study protocol of a pragmatic multi-center cluster-randomized controlled prevention trial against cognitive decline in older primary care patients

BMC Geriatrics
Andrea ZülkeSteffi G Riedel-Heller

Abstract

In the absence of treatment options, the WHO emphasizes the identification of effective prevention strategies as a key element to counteract the dementia epidemic. Regarding the complex nature of dementia, trials simultaneously targeting multiple risk factors should be particularly effective for prevention. So far, however, only few such multi-component trials have been launched, but yielding promising results. In Germany, comparable initiatives are lacking, and translation of these complex interventions into routine care was not yet done. Therefore, AgeWell.de will be conducted as the first multi-component prevention trial in Germany which is closely linked to the primary care setting. AgeWell.de will be designed as a multi-centric, cluster-randomized controlled multi-component prevention trial. Participants will be older community-dwelling general practitioner (GP) patients (60-77 years; n = 1,152) with increased dementia risk according to CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) Dementia Risk Score. Recruitment will take place at 5 study sites across Germany. GP practices will be randomized to either intervention A (advanced) or B (basic). GPs will be blinded to their respective group assignment,...Continue Reading

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Citations

Jul 7, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miia KivipeltoMaria C Carrillo
Sep 3, 2020·Fortschritte der Neurologie-Psychiatrie·Jens BohlkenKarel Kostev
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Nov 9, 2021·The Cochrane Database of Systematic Reviews·Melanie HafdiEdo Richard

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Software Mentioned

MoodGym
AgeWell
AiD
NeuroNation
SAS
SPSS
CDISC ODM

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