PMID: 9180370Jan 1, 1997Paper

Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice

Life Sciences
M TsudaM Misawa

Abstract

The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro-L-arginine (NOARG; 8 mg/kg) and N-nitro-L-arginine methyl ester (L-NAME; 100 mg/kg), but not with D-NAME. Furthermore, these NOS inhibitors also decreased the threshold for pentylenetetrazole-induced seizure. However, the threshold for caffeine-induced seizure was not affected by NOARG. These results suggest that the endogenous NO system may play an important role in the expression of seizure by GABA(A) receptor inhibitory agents (DMCM and PTZ).

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Citations

Aug 9, 2003·Neuropharmacology·Shadpour DemehriAhmad Reza Dehpour
Feb 2, 2002·Epilepsy Research·Houman HomayounAhmad Reza Dehpour
Mar 13, 2012·Epilepsy & Behavior : E&B·Leila MoeziAhmad Reza Dehpour
Feb 14, 2006·British Journal of Pharmacology·Kiarash RiaziAhmad Reza Dehpour
Jun 10, 2008·British Journal of Pharmacology·Sy Inan, K Büyükafşar
Jun 28, 2014·Epilepsy & Behavior : E&B·Elahe SattarinezhadLeila Moezi
Jun 18, 2010·European Journal of Pharmacology·Nobuyoshi HasebeOsamu Inoue
Aug 16, 2008·Epilepsy & Behavior : E&B·Taha GholipourAhmad Reza Dehpour
Jan 13, 2006·Epilepsy Research·Noushin Yahyavi-Firouz-AbadiAhmad Reza Dehpour
Mar 16, 2002·Journal of Gastroenterology and Hepatology·Houman HomayounAmad Reza Dehpour
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jong-Seon ByunWanjoo Chun
Jul 28, 2010·Behavioural Pharmacology·Liga ZvejnieceMaija Dambrova
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Charles Kwaku BennehEric Woode

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