Aggregate exposure of the adult French population to pyrethroids

Toxicology and Applied Pharmacology
Keyvin DarneyVirginie Desvignes

Abstract

The French Nutrition and Health Survey (ENNS) reported higher biomarker levels of exposure to pyrethroids than those observed in North American and German biomonitoring studies. The authors therefore investigated aggregate exposure to permethrin as an initial case study because this compound is one of the most widely-used pyrethroid insecticides. We assessed several contamination sources-such as indoor and outdoor air, settled dust and diet-and several pathways, including oral, inhalation and dermal routes. We used permethrin exposure level estimations (computed from ENNS data) and a PBPK model calibrated with human kinetic data (from 6 individuals) to simulate an internal dose of cis- and trans-3-(2,2 dichlorovinyl)-2,2-dimethyl-(1-cyclopropane) carboxylic acid (cis- or trans-DCCA) in a population of 219 individuals. The urinary concentrations of cis- and trans -DCCA predicted by the PBPK model according to three permethrin exposure scenarios ("lower", "intermediate", and "upper"), were compared to the urinary levels measured in the ENNS study. The ENNS levels were between the levels simulated according to permethrin exposure scenarios "lower" and "intermediate". The "upper" scenario led to an overestimation of the predicted u...Continue Reading

References

Mar 1, 1991·The British Journal of Nutrition·P DeurenbergJ C Seidell
Mar 30, 1984·Toxicology and Applied Pharmacology·J C Ramsey, M E Andersen
Jul 1, 1997·Toxicology and Industrial Health·R P BrownR P Beliles
Jul 22, 1999·Toxicology Letters·W Butte, K Kemper
Feb 3, 2005·Environmental Health Perspectives·Timothy J ShaferKevin M Crofton
Jul 13, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ahmad MirfazaelianJeffrey W Fisher
Oct 25, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Edward J ScollonMichael F Hughes
May 12, 2009·Reproductive Toxicology·John D MeekerRuss Hauser
Jun 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hao-Jie ZhuJohn S Markowitz
Aug 4, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rogelio Tornero-VelezMichael F Hughes
Mar 7, 2013·Journal of Exposure Science & Environmental Epidemiology·Binnian WeiClifford P Weisel
Oct 1, 2013·Environmental Health Perspectives·Wendy McKelveyKenneth M Aldous
Jun 15, 2014·Journal of Pharmacological and Toxicological Methods·Pankaj K SethiCatherine A White
Dec 17, 2014·Toxicology Letters·Mylène RatelleMichèle Bouchard
Mar 15, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M-E WilleminC Brochot
Jan 16, 2016·Occupational and Environmental Medicine·Ming YeAmbikaipakan Senthilselvan
May 18, 2016·Environmental Research·Xu WangZonghui Yuan
Aug 12, 2017·Risk Analysis : an Official Publication of the Society for Risk Analysis·Marie HermantVirginie Desvignes

❮ Previous
Next ❯

Citations

Jun 28, 2019·Arhiv za higijenu rada i toksikologiju·Hamidreza MohammadiSorour Ashari
Jun 22, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bruce A BuchholzBruce D Hammock
Jul 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Marie VanackerAmélie Crépet
Aug 31, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bruce A BuchholzBruce D Hammock

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Risk Analysis : an Official Publication of the Society for Risk Analysis
Marie HermantVirginie Desvignes
Toxicological Sciences : an Official Journal of the Society of Toxicology
Rogelio Tornero-VelezMichael F Hughes
Journal of Exposure Science & Environmental Epidemiology
Binnian WeiClifford P Weisel
© 2022 Meta ULC. All rights reserved