Aggregatibacter actinomycetemcomitans-Induced AIM2 Inflammasome Activation Is Suppressed by Xylitol in Differentiated THP-1 Macrophages

Journal of Periodontology
Seyeon KimJin Chung

Abstract

Aggressive periodontitis is characterized by rapid destruction of periodontal tissue caused by Aggregatibacter actinomycetemcomitans. Interleukin (IL)-1β is a proinflammatory cytokine, and its production is tightly regulated by inflammasome activation. Xylitol, an anticaries agent, is anti-inflammatory, but its effect on inflammasome activation has not been researched. This study investigates the effect of xylitol on inflammasome activation induced by A. actinomycetemcomitans. The differentiated THP-1 macrophages were stimulated by A. actinomycetemcomitans with or without xylitol and the expressions of IL-1β and inflammasome components were detected by real time PCR, ELISA, confocal microscopy and Immunoblot analysis. The effects of xylitol on the adhesion and invasion of A. actinomycetemcomitans to cells were measured by viable cell count. A. actinomycetemcomitans increased pro IL-1β synthesis and IL-1β secretion in a multiplicity of infection- and time-dependent manner. A. actinomycetemcomitans also stimulated caspase-1 activation. Among inflammasome components, apoptosis-associated speck-like protein containing a CARD (ASC) and absent in melanoma 2 (AIM2) proteins were upregulated by A. actinomycetemcomitans infection. When ...Continue Reading

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Citations

Sep 3, 2016·Nutrients·Shariq NajeebKhalid Almas
Jan 22, 2020·Journal of Periodontal Research·Kübra AralPaul R Cooper
Mar 15, 2020·Journal of Periodontology·Hyun Ah LeeJin Chung
Sep 27, 2019·Journal of Periodontology·Kübra AralAfig Berdeli
Nov 9, 2019·European Journal of Oral Sciences·Farah Asa'adLena Larsson
Jan 5, 2020·International Journal of Oral Science·Ran ChengTao Hu
Sep 10, 2020·Frontiers in Immunology·Lufei WangJie Fang
Jul 12, 2017·Journal of Periodontology·Diana M Isaza-GuzmánSergio I Tobón-Arroyave
Jan 13, 2021·Journal of Clinical Medicine·Prescilla MartinonFlorence Carrouel
Jun 29, 2021·Frontiers in Immunology·Yang LiQianzhou Jiang

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