PMID: 9423861Jan 10, 1998Paper

Aggregation and binding substances enhance pathogenicity in rabbit models of Enterococcus faecalis endocarditis

Infection and Immunity
P M SchlievertG M Dunny

Abstract

We investigated the importance of enterococcal aggregation substance (AS) and enterococcal binding substance (EBS) in rabbit models of Enterococcus faecalis cardiac infections. First, American Dutch belted rabbits were injected intraventricularly with 10(8) CFU and observed for 2 days. No clinical signs of illness developed in animals given AS- EBS- organisms, and all survived. All rabbits given AS- EBS+ organisms developed signs of illness, including significant pericardial inflammation, but only one of six died. All animals given AS+ EBS- organisms developed signs of illness, including pericardial inflammation, and survived. All rabbits given AS+ EBS+ organisms developed signs of illness and died. None of the rabbits receiving AS+ EBS+ organisms showed gross pericardial inflammation. The lethality and lack of inflammation are consistent with the presence of a superantigen. Rabbit and human lymphocytes were highly stimulated in vitro by cell extracts, but not cell-free culture fluids, of AS+ EBS+ organisms. In contrast, cell extracts from AS- EBS- organisms weakly stimulated lymphocyte proliferation. Culture fluids from human lymphocytes stimulated with AS+/EBS+ enterococci contained high levels of gamma interferon and tumor n...Continue Reading

References

Sep 16, 1991·The American Journal of Medicine·D R SchabergR P Gaynes
Dec 1, 1991·Infection and Immunity·S BhakdiW Fischer
Apr 1, 1981·The Journal of Infectious Diseases·P M SchlievertR D Nishimura
Dec 1, 1995·Infection and Immunity·D Burnette-CurleyF L Macrina
Oct 1, 1993·The Annals of Pharmacotherapy·S A TailorM J Rybak
Jan 1, 1996·The Journal of Laboratory and Clinical Medicine·P M SchlievertP P Cleary
Mar 1, 1997·Infection and Immunity·H B ViscountF L Macrina

❮ Previous
Next ❯

Citations

Aug 4, 2004·Microbiology·Régis StentzClaire Shearman
Mar 24, 2004·Nature Reviews. Microbiology·Eric Cascales, Peter J Christie
Mar 17, 2012·Nature Reviews. Microbiology·Cesar A Arias, Barbara E Murray
Jul 7, 2012·PloS One·Dominik Alexander BloesDorothee Kretschmer
Mar 6, 2013·Infection and Immunity·Kristi L FrankGary M Dunny
Sep 21, 2013·Annual Review of Genetics·Gary M Dunny
Jul 8, 2014·Nature Reviews. Microbiology·Wilmara Salgado-Pabón, Patrick M Schlievert
Mar 30, 2016·Journal of Bacteriology·Gary M Dunny, Ronnie Per-Arne Berntsson
Jan 20, 2020·Probiotics and Antimicrobial Proteins·Alexander Suvorov
Nov 30, 2000·Current Infectious Disease Reports·J K McCormickP M Schlievert
Apr 3, 2004·Journal of Bacteriology·Alexa A PragmanPatrick M Schlievert
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Francis C Neuhaus, James Baddiley
Sep 13, 2003·Cellular Microbiology·Phillip S Coburn, Michael S Gilmore
Sep 30, 2008·Journal of Immunoassay & Immunochemistry·Yun Sang ChoPan Dong Ryu
Dec 21, 2013·The Journal of Infectious Diseases·Adam R SpauldingPatrick M Schlievert
Jun 5, 2012·Current Infectious Disease Reports·Jose M MunitaBarbara E Murray
Jun 1, 2016·Frontiers in Microbiology·David Perez-PascualRozenn Gardan
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emanuel N VergisRobert R Muder
Oct 7, 2009·Journal of Applied Microbiology·A R CarlosR Tenreiro
Oct 22, 2011·Mobile Genetic Elements·Don B Clewell
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Medora J HusebyCathleen A Earhart
Jul 31, 2012·Applied and Environmental Microbiology·Sabina Leanti La RosaDag Anders Brede
Oct 28, 2016·Molecular Microbiology·Minny BhattyPeter J Christie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.