Aggregation and deformability of erythrocytes in primary open-angle glaucoma (POAG); the assessment of arterial hypertension

Clinical Hemorheology and Microcirculation
Katarzyna Michalska-Małecka, Ludmiła Słowińska-Łozyńska

Abstract

Primary open-angle glaucoma (POAG) is one of the most common types of glaucoma. Glaucoma is a progressive neuropathy of the optic nerve with characteristic visual area disorders. The aim of this study was to assess the correlations between rheological parameters of blood and other parameters such as: intraocular pressure, visual acuity, angular breadth of the aqueous fluid eluvium, visual area and arterial hypertension. The examined group was comprised of 54 patients with POAG. Out of this group two subgroups was separated: I subgroup of 24 patients without hypertensive and II subgroup of 30 patients with chronic hypertensive disease. The control group was comprised of 40 healthy subjects. Erythrocyte aggregation and deformability analysis were determined using LORCA. From the results we concluded that rheological disorders such as enhanced erythrocyte aggregation or significantly decreased erythrocyte deformability occur in patients with POAG. Additionally, it revealed a significant relation between the duration of hypertension and an increased erythrocyte aggregation index (r = +0.27 p < 0.005) along with decreased deformability (r = -0.37 p < 0.001), where the decrease in deformability correlated with the severity of hyperto...Continue Reading

Citations

May 16, 2013·Cell Biochemistry and Biophysics·Magdalena KaczmarskaKvetoslava Burda
Oct 27, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Emine Kilic-ToprakMelek Bor-Kucukatay
May 11, 2016·Clinical Hemorheology and Microcirculation·Katarzyna Michalska-MałeckaJustyna Sierocka-Stępień
Sep 12, 2015·Biological Trace Element Research·Qiuyue ZhangYanfei Li
Jun 1, 2021·Clinical Hemorheology and Microcirculation·Maria FornalTomasz Grodzicki

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