Aggregation-fragmentation model of robust concentration gradient formation

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Timothy E Saunders

Abstract

Concentration gradients of signaling molecules are essential for patterning during development and they have been observed in both unicellular and multicellular systems. In subcellular systems, clustering of the signaling molecule has been observed. We develop a theoretical model of cluster-mediated concentration gradient formation based on the Becker-Döring equations of aggregation-fragmentation processes. We show that such a mechanism produces robust concentration gradients on realistic time and spatial scales so long as the process of clustering does not significantly stabilize the signaling molecule. Finally, we demonstrate that such a model is applicable to the pom1p subcellular gradient in fission yeast.

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P G Saffman, M Delbrück
Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Sep 3, 1999·FEBS Letters·G C Brown, B N Kholodenko
Sep 5, 2001·Molecular Microbiology·J R RobbinsJ A Theriot
Oct 11, 2003·Developmental Cell·Avigdor EldarNaama Barkai
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·George H Wadhams, Judith P Armitage
Feb 9, 2005·Physical Review Letters·T BollenbachF Jülicher
Mar 24, 2005·Physical Review Letters·Jeremy L England, John Cardy
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Y GambinW Urbach
Feb 17, 2006·Nature Reviews. Molecular Cell Biology·Boris N Kholodenko
Sep 5, 2006·Current Biology : CB·Jason MeyersDavid J Odde
Jan 27, 2007·Science·Anna KichevaMarcos González-Gaitán
May 1, 2007·PLoS Computational Biology·Filipe TostevinMartin Howard
Jul 17, 2007·Cell·Thomas GregorDavid W Tank
Nov 16, 2007·Developmental Biology·Mathieu CoppeyStanislav Y Shvartsman
May 29, 2009·Nature·Sophie G Martin, Martine Berthelot-Grosjean
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Timothy E Saunders, Martin Howard
Aug 5, 2010·Biophysical Journal·Feng HeJun Ma
Sep 28, 2010·Physical Review Letters·Bo HuHerbert Levine
Dec 29, 2010·PLoS Computational Biology·Marco VilelaPaul A Lindahl
Jan 20, 2011·Biophysical Journal·Filipe Tostevin
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Katherine W Rogers, Alexander F Schier
Nov 22, 2011·PLoS Computational Biology·Alexandra JilkineSteven J Altschuler
Feb 22, 2012·Developmental Cell·Timothy E SaundersFred Chang
Mar 9, 2012·The Journal of Physical Chemistry. B·Sarah L VeatchBarbara A Baird
Apr 17, 2012·Trends in Cell Biology·Martin Howard
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aryeh WarmflashAli H Brivanlou
Aug 31, 2012·BMC Biophysics·Carolina TropiniKerwyn Casey Huang
Mar 28, 2013·Development·Patrick MüllerAlexander F Schier
Apr 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Feng LiuThomas Gregor
Jun 12, 2013·Current Opinion in Genetics & Development·Ana-Citlali Gradilla, Isabel Guerrero
Jun 19, 2013·Developmental Cell·Changhwan LeeAmy S Gladfelter
Nov 5, 2013·Current Biology : CB·Binh-An Truong QuangPierre-François Lenne
Dec 18, 2013·Trends in Microbiology·Daniela Kiekebusch, Martin Thanbichler
Mar 20, 2014·ELife·Kally Z PanFred Chang
Jul 2, 2014·The Journal of Cell Biology·Sergio A RinconAnne Paoletti
Jul 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jacques P BothmaMichael Levine

❮ Previous
Next ❯

Citations

Sep 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Duso, Christoph Zechner
Jul 4, 2018·Physical Chemistry Chemical Physics : PCCP·Wojciech Jeżewski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biotechnology
M Yamamoto
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
T IsshikiM Yamamoto
© 2021 Meta ULC. All rights reserved