Oct 1, 1976

Aggregation of antiacetylcholine drugs in aqueous solution: monomer concentrations in non-micellar drug systems

The Journal of Pharmacy and Pharmacology
D Attwood

Abstract

The self-association of the antiacetylcholine drugs, propantheline bromide, methantheline bromide and methixene hydrochloride in aqueous solution, has been examined by surface tension, light scattering and conductimetric methods. Surface tension graphs were similar to those of conventional surfactants, showing apparent critical micelle concentrations (cmc) at distinct inflection points. Surface tension measurements in the presence of increasing amounts of electrolyte indicated a decrease in the apparent cmc with increase in electrolyte concentration for propantheline bromide. Light scattering curves for propantheline bromide in electrolyte solution showed no significant discontinuity attributable to a cmc. A mode of self association involving aggregate growth by the stepwise addition of monomers was assumed and equilibrium constants for the initial stages of the association were evaluated. An increase in the magnitude of the stepwise association constants with increase in electrolyte concentration was noted. Integration of the light scattering data according to 1n x = oo [(M/Mapp) - 1] dln c (where M and M app are the monomer and apparent aggregate weights respectively and x is the weight fraction of monomers) showed an asympto...Continue Reading

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Mentioned in this Paper

Drug Formulation Process
Electrolytes
Propantheline Bromide
Propantheline
Oral electrolyte solution
Aggregation
Interfacial Force
Digestive Surfactants
Methantheline bromide
Chudley-Mccullough Syndrome

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