PMID: 6747May 1, 1976

Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives

The Journal of Pharmacy and Pharmacology
D Attwood


Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride, chlorphenoxamine hydrochloride, lachesine hydrochloride, poldine methylsulphate, pipenzolate bromide, clidinium bromide, benzilonium bromide and ambutonium bromide. A micellar pattern of association was established for all compounds and critical micellar concentrations and aggregation numbers have been determined.


Nov 1, 1975·The Journal of Pharmacy and Pharmacology·D Attwood, O K Udeala
Oct 1, 1975·The Journal of Pharmacy and Pharmacology·D Attwood, O K Udeala
Nov 1, 1974·The Journal of Pharmacy and Pharmacology·D Attwood, O K Udeala
Feb 1, 1972·Journal of Pharmaceutical Sciences·A Felmeister
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·D Attwood


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Related Concepts

Acetylcholine Sulfate (1: 1)
Biphenyl Compounds
Drug Formulation Process
Scattering, Radiation

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