Aggregation of nanoparticles regulated by mechanical properties of nanoparticle-membrane system

Nanotechnology
Huayuan TangYonggang Zheng

Abstract

The aggregation of nanoparticles (NPs) on the cell membrane is crucial for the cellular uptake process and has important biological implications in protein-membrane interactions. In this paper, we systematically investigate how the aggregation is regulated by the mechanical properties of the NP-membrane system, including the membrane tension, and the size and shape of the NPs. Results show that when NPs aggregate parallel to the cell membrane, increasing the membrane tension will modulate the membrane-mediated interaction between the NPs from attractive to attractive-repulsive and finally to purely repulsive. In contrast, the membrane-mediated interaction is attractive and independent of the membrane tension when the NPs aggregate to a tubular configuration. For the aggregation of NPs of different sizes, the large-size NP is wrapped to a greater extent than the small-size NP. For the aggregation of nonspherical NPs, low aspect ratio and weak NP-membrane adhesion strength lead to the side-to-side configuration, whereas a system with a high aspect ratio and strong NP-membrane adhesion strength prefers the tip-to-tip configuration. Importantly, NPs of different sizes and anisotropic shapes are found to facilitate the aggregation p...Continue Reading

References

Feb 7, 1991·Nature·R Lipowsky
Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Apr 20, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Markus Deserno
Feb 9, 2005·Physical Review Letters·J C LoudetA G Yodh
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huajian GaoLambert B Freund
Feb 4, 2006·Science·Andre NelNing Li
Oct 3, 2006·PLoS Pathogens·Takeshi NodaYoshihiro Kawaoka
Nov 4, 2006·Advanced Drug Delivery Reviews·Chien-Chi Lin, Andrew T Metters
Dec 13, 2006·Biophysical Journal·Nitzan KolItay Rousso
Jun 24, 2009·Nanotechnology·Y C OuW B Jian
Sep 10, 2009·Nanotechnology·P Y ChenY L Shao
Mar 3, 2010·Small·Xinghua ShiHuajian Gao
Nov 4, 2011·Nano Letters·Robert VáchaDaan Frenkel
Dec 12, 2012·Physical Review Letters·Anđela Šarić, Angelo Cacciuto
Dec 12, 2012·Physical Review Letters·Amir Houshang BahramiThomas R Weikl
Aug 27, 2013·Nano Letters·Changjin HuangSulin Zhang
Nov 12, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Hossein Rezvantalab, Shahab Shojaei-Zadeh
Nov 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mijo SimunovicGregory A Voth
Jan 5, 2014·Nano Letters·Sabyasachi DasguptaGerhard Gompper
Jan 28, 2014·Nano Letters·Xin YiHuajian Gao
Mar 25, 2014·Soft Matter·Michael RaatzThomas R Weikl
Sep 17, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Sabyasachi DasguptaGerhard Gompper
Feb 25, 2015·Advances in Colloid and Interface Science·Charlotte M BeddoesWuge H Briscoe
May 27, 2015·Nature Communications·Mijo Simunovic, Gregory A Voth
Aug 11, 2015·ACS Nano·Sulin ZhangGang Bao
Dec 15, 2015·Physical Chemistry Chemical Physics : PCCP·Tongtao YueFang Huang
Sep 14, 2016·Scientific Reports·Casper van der WelDaniela J Kraft
Jun 14, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·S DasguptaG Gompper
Jul 6, 2017·Soft Matter·Afshin VahidTimon Idema
Sep 2, 2017·Chemical Reviews·Calum KinnearAlke Petri-Fink
Dec 5, 2017·The Journal of Physical Chemistry. B·Huayuan TangYonggang Zheng
Dec 7, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Chunbao DuKaiyang Zeng
Dec 28, 2017·Nano Letters·Amir Houshang Bahrami, Thomas R Weikl
Jan 18, 2018·Physical Chemistry Chemical Physics : PCCP·Falin TianXianren Zhang

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Citations

Feb 6, 2020·Biomedical Optics Express·Iris Aguilar-HernándezNancy Ornelas-Soto
Jul 16, 2019·ACS Applied Materials & Interfaces·Zhongqiang ZhangShaofan Li

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