Aggresomes resemble sites specialized for virus assembly

The Journal of Cell Biology
C M HeathT Wileman

Abstract

The large cytoplasmic DNA viruses such as poxviruses, iridoviruses, and African swine fever virus (ASFV) assemble in discrete perinuclear foci called viral factories. Factories exclude host proteins, suggesting that they are novel subcellular structures induced by viruses. Novel perinuclear structures, called aggresomes are also formed by cells in response to misfolded protein (Johnston, J.A., C.L. Ward, and R.R. Kopito. 1998. J. Cell Biol. 143:1883--1898; García-Mata, R., Z. Bebök, E.J. Sorscher, and E.S. Sztul. 1999. J. Cell Biol. 146:1239--1254). In this study, we have investigated whether aggresomes and viral factories are related structures. Aggresomes were compared with viral factories produced by ASFV. Aggresomes and viral factories were located close to the microtubule organizing center and required an intact microtubular network for assembly. Both structures caused rearrangement of intermediate filaments and the collapse of vimentin into characteristic cages, and both recruited mitochondria and cellular chaperones. Given that ASFV factories resemble aggresomes, it is possible that a cellular response originally designed to reduce the toxicity of misfolded proteins is exploited by cytoplasmic DNA viruses to concentrate ...Continue Reading

References

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Citations

Jun 14, 2005·Trends in Microbiology·Katinka DöhnerBeate Sodeik
May 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Caryn NavarroRuth Lehmann
Apr 12, 2013·Journal of Virology·D P GladueM V Borca
Dec 26, 2008·Journal of Virology·Christopher L NethertonGeraldine Taylor
Oct 23, 2009·Journal of Virology·Cristina SuárezJavier M Rodríguez
Aug 17, 2005·Journal of Virology·Felipe D AraujoMatthew D Weitzman
Sep 28, 2007·Annual Review of Microbiology·Thomas Wileman
Jan 24, 2007·BMC Molecular Biology·Alak Kanti KarPolly Roy
Jan 13, 2011·Virology Journal·Suchita Bhattacharyya, Thomas J Hope
Jun 22, 2012·PLoS Pathogens·Elena G SánchezYolanda Revilla
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Manuela MuraMassimo Palmarini
Feb 28, 2002·The EMBO Journal·Edda FiebigerDomenico Tortorella
May 30, 2002·The Journal of Cell Biology·Brian T HelfandRobert D Goldman
Jan 29, 2016·Reviews in Medical Virology·Laura de Armas-RilloAgustín Valenzuela-Fernández
Dec 25, 2012·Virus Research·Covadonga AlonsoRaquel Muñoz-Moreno

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Methods Mentioned

BETA
protein folding
Immunoprecipitation
transfecting

Software Mentioned

Openlab
Improvision

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