Aggression is suppressed by acute stress but induced by chronic stress: immobilization effects on aggression, hormones, and cortical 5-HT(1B)/ striatal dopamine D(2) receptor density.

Cognitive, Affective & Behavioral Neuroscience
Laurel R YoheLouis R Lucas

Abstract

Although it has been established by a number of investigators that a variety of stressors are associated with the induction of aggressive behavior, two specific issues remain unanswered. First, it is unclear whether the contexts surrounding stressors (e.g., stressor length and chance of winning over opponents) change outcomes regarding aggressive behavior. Second, if a relationship exists between stress and aggressive behavior, altered levels of stress-related hormone (e.g., corticosterone [CORT]), as well as aggression-related biomarkers (e.g., testosterone [T], density of prefronto-cortical 5-HT(1B) receptor and striatal dopamine D(2) receptor [D2r]) may contribute to changes in aggressive behavior. Thus, we examined how immobilization (with a 1-, 5-, or 10-day exposure) would impact (1) a longitudinal course of aggression toward different-sized opponents, (2) levels of CORT and T, and (3) densities of 5-HT(1B) receptor (5-HT1Br) in the prefrontal cortex (PFC) and D2r in the striatum. It was found that, regardless of small or large opponents, a single 2-h exposure to immobilization reduced aggressive behavior (stress-suppressed aggression) over time, whereas repeated (10-day) exposure to immobilization escalated aggressive be...Continue Reading

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Citations

Apr 2, 2013·Journal of Physiology, Paris·Guillaume Bronsard, Fabrice Bartolomei
Jul 6, 2014·Hearing Research·Adam R SmithLaura M Hurley
Feb 5, 2015·Cognitive, Affective & Behavioral Neuroscience·Hideo Suzuki, Louis R Lucas
Apr 22, 2015·Nature Reviews. Neuroscience·Carmen Sandi, József Haller
Jan 23, 2015·Frontiers in Behavioral Neuroscience·Anne NosjeanSylvie Granon

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