DOI: 10.1101/462382Nov 7, 2018Paper

Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

BioRxiv : the Preprint Server for Biology
Julia E WerhahnDaniel Brandeis


ObjectiveThere is increasing evidence to suggest altered resting state functional connectivity (rsFC) in adolescents with conduct problems. However, no rsFC studies have addressed the effects of reactive and proactive aggression. Herein, we examined the associations between these aggression subtypes along with subdimensions of callous-unemotional (CU) traits and rsFC using predefined seeds in aggression-related salience network (SN) and default mode network (DMN).\n\nMethodAggression subtype-specific whole-brain rsFC of SN and DMN seeds was investigated in a resting state sequence (mean acquisition time = 8 min 25 sec) acquired from 207 children and adolescents of both sexes aged 8 - 18 years (mean age (SD) = 13.30 (2.60) years; range = 8.02 - 18.35) in a multi-center study. One hundred eighteen individuals exhibited disruptive behavior (conduct disorder/oppositional defiant disorder) with different levels of comorbid ADHD symptoms, 89 were healthy.\n\nResultsCompared to healthy controls, cases demonstrated reduced DMN and - after controlling for ADHD scores - SN seed-based rsFC with left hemispheric frontal clusters. We found increased and distinct aggression-subtype specific rsFC patterns in brain regions linked to processes ...Continue Reading

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