Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover

Aggressive Behavior
Elena L GrigorenkoCarolyn M Yrigollen

Abstract

A number of dopamine-related genes have been implicated in the etiology of violent behavior and conduct problems. Of these genes, the ones that code for the enzymes that influence the turnover of dopamine (DA) have received the most attention. In this study, we investigated 12 genetic polymorphisms in four genes involved with DA functioning (COMT, MAOA and MAOB, and DbetaH) in 179 incarcerated male Russian adolescents and two groups of matched controls: boys without criminal records referred to by their teachers as (a) "troubled-behavior-free" boys, n=182; and (b) "troubled-behavior" boys, n=60. The participants were classified as (1) being incarcerated or not, (2) having the DSM-IV diagnosis of conduct disorder (CD) or not, and (3) having committed violent or nonviolent crimes (for the incarcerated individuals only). The findings indicate that, although no single genetic variant in any of the four genes differentiated individuals in the investigated groups, various linear combinations (i.e., haplotypes) and nonlinear combinations (i.e., interactions between variants within and across genes) of genetic variants resulted in informative and robust classifications for two of the three groupings. These combinations of genetic varia...Continue Reading

References

Aug 1, 1988·Biological Psychiatry·S KupermanJ Loney
Mar 1, 1982·The American Journal of Psychiatry·G A RogenessE L Mitchell
Apr 1, 1980·Acta Psychiatrica Scandinavica·C PerrisH Perris
Jun 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·M Kovacs, M Pollock
Jan 1, 1997·Journal of Personality and Social Psychology·D R Miles, G Carey
Aug 17, 2000·Clinical Genetics·D E ComingsJ P MacMurray
Apr 26, 2001·Scandinavian Journal of Psychology·W A ArrindellM Gustafsson
Mar 12, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Vladislav V RuchkinHans Steiner
Aug 6, 2002·Science·Avshalom CaspiRichie Poulton
Aug 13, 2002·Annual Review of Psychology·Robert Plomin, Peter McGuffin
Dec 10, 2002·Archives of General Psychiatry·Linda A TeplinAmy A Mericle
Apr 17, 2003·Journal of the American Academy of Nurse Practitioners·Mikel Gray
Jun 5, 2003·The American Journal of Psychiatry·R Andrew ChambersMarc N Potenza
Jun 13, 2003·American Journal of Human Genetics·Nicholas J BrayMichael C O'Donovan
Nov 12, 2003·Archives of General Psychiatry·Karen M AbramMina K Dulcan
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sagiv ShifmanAriel Darvasi
Nov 4, 2004·Trends in Genetics : TIG·Tricia A Thornton-WellsJonathan L Haines
Nov 5, 2004·Expert Review of Molecular Diagnostics·Jason H Moore
Dec 14, 2004·Nature Genetics·Daniel SegrèRoy Kishony
Dec 30, 2004·Nature Genetics·Jason H Moore
Feb 9, 2005·American Journal of Preventive Medicine·Robert A HahnUNKNOWN Task Force on Community Preventive Services
Feb 22, 2005·Developmental Science·Jim StevensonErik Willcutt
Jul 20, 2005·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Robert J McMahon, Paul J Frick
Feb 3, 2006·BMC Genetics·Christy L AveryKari E North

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Citations

Jul 5, 2013·Journal of Forensic Sciences·Claudio TerranovaSanto D Ferrara
Jul 5, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Mary Jane BentleyJames F Leckman
Nov 12, 2016·The Psychiatric Clinics of North America·Jonathan M MeyerStephen M Stahl
Mar 21, 2018·International Journal of Legal Medicine·Tanja ČuguraAlja Videtič Paska

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