Aggressive characteristics of myeloblasts expressing CD7 in myelodysplastic syndromes

Leukemia Research
Chikako SatohKiyoyuki Ogata

Abstract

Clinical data suggest that CD7+ myeloblasts are linked with poor prognosis in myeloid malignancies including myelodysplastic syndromes (MDS). To explore the biology behind this, we compared cell characteristics between CD34+CD7+ and CD34+CD7- myeloblasts from an MDS cell line and fresh samples from MDS patients. Compared with CD34+CD7- myeloblasts, CD34+CD7+ myeloblasts showed greater proliferative capacity, more active cell cycling, and less apoptosis. In analyses of a cell line, CD34+CD7+ myeloblasts produced CD34+CD7- myeloblasts and showed lower expressions of interleukin-8 and chemokine (C-C motif) ligand 2 genes, suggesting immaturity of these cells. These findings might underlie the clinical aggressiveness in CD7+ MDS.

References

Aug 4, 2001·Immunologic Research·R Stillwell, B E Bierer
Sep 3, 2003·European Journal of Haematology·Are P NormannGeir E Tjønnfjord
Nov 16, 2004·Biochemical and Biophysical Research Communications·Kazuhisa NakaoTakashi Tsuji
Aug 20, 2005·Leukemia & Lymphoma·Kiyoyuki Ogata, Yataro Yoshida
Mar 28, 2006·Journal of Neuroimmunology·Jun-ichi SatohTakashi Yamamura
May 9, 2007·Leukemia Research·Yumiko ShioiKiyoyuki Ogata

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Citations

Apr 20, 2010·Journal of Hematology & Oncology·Sonja RöhrsHilmar Quentmeier
Apr 9, 2013·Pediatric Hematology and Oncology·Müsemma KarabelMeki Bilici
Aug 31, 2017·Journal of Hematology & Oncology·Mingxue FanLei Yu

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