PMID: 9160318May 1, 1997Paper

Aggressive gastric peripheral T-cell lymphoma of CD8+ type associated with lymphomatous meningitis

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
V A HolstS H Swerdlow

Abstract

Most gastric lymphomas are of B-cell origin, and many are either low-grade or high-grade B-cell lymphomas of mucosa-associated lymphoid tissue type. Gastric T-cell lymphomas are very rare, usually of CD4+ type, and few have had genotypic studies. We report the case of a gastric peripheral T-cell lymphoma of CD8+ type. Genotypic studies demonstrated partial deletion with rearrangement of the T-cell receptor beta-chain gene. Lymphomatous meningitis developed, and the patient died after only 2 months despite chemotherapy. The case is compared with the other gastric T-cell lymphomas that have been reported.

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