Aggressive giant cell lesion of the jaws: a review of management options and report of a mandibular lesion treated with denosumab

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
J E O'ConnellG J Kearns

Abstract

Giant cell lesions (GCLs), previously referred to as giant cell granulomas, are benign tumors of the jaws of unknown etiology. Surgical management of aggressive GCLs is challenging, as these lesions demonstrate a tendency to recur following surgical removal. In addition, surgical treatment can be associated with significant morbidity. In an attempt to reduce both the extent of morbidity and the recurrence rate following surgery, a number of pharmacologic therapies have been advocated on the basis of assumptions about the predominant cell types and receptors, for the management of these lesions. This report describes the use of denosumab, an agent originally used for its anti-resorptive effects, in the management of an aggressive GCL of the mandible in an older patient, who was unsuitable for extensive surgery and in whom treatment with intralesional triamcinolone had proved unsuccessful. Denosumab may be a viable alternative or adjunct to surgery in the management of GCLs of the jaws.

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Citations

Feb 24, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·John Edward O'Connell, Gerard J Kearns
Oct 19, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Renato Luiz Maia NogueiraRicardo Teixeira Abreu
Mar 8, 2019·Current Opinion in Oncology·Astrid LipplaaHans Gelderblom
Nov 7, 2019·JBMR Plus·Alexander Upfill-BrownNoah C Federman
Jan 18, 2020·Head and Neck Pathology·Jen-Chieh Lee, Hsuan-Ying Huang
Mar 25, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Bruno Augusto Linhares Almeida MarizAndré Caroli Rocha

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