Aggressive Hydration With Ringer's Lactate in the Prevention of Post-ERCP Pancreatitis: A Meta-Analysis.

Curēus
Samar Aljohani, Hyder Mirghani

Abstract

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a dangerous complication and occurs in a considerable number of patients. However, since well-randomized controlled trials investigating aggressive hydration with Ringer's lactate are lacking, this meta-analysis assessed the role of aggressive hydration with Ringer's lactate alone or in combination with other therapies in the prevention of PEP. We searched PubMed, Cochrane Library, and Google Scholar for relevant articles. The search engine was set to randomize controlled trials and prospective cohorts assessing Ringer's lactate in PEP prevention either alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) and stent. The keywords "aggressive hydration," "Ringer's lactate," "post-ERCP pancreatitis," "NSAIDs," "stent placement," and "somatostatin analogs" were used. The search was limited to a study on humans published in English with no limitation to the study period. Two hundred and six articles were retrieved. Only eight articles fulfilled the inclusion criteria. The studies showed a reduction of post-ERCP pancreatitis using aggressive hydration with Ringer's lactate alone (odds ratio 0.23, 95% CI 0.13 - 0.40, P-value < 0.001...Continue Reading

References

Aug 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·James BuxbaumLoren Laine
Aug 7, 2019·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Dhruvil RadadiyaChakradhar Reddy
Aug 30, 2019·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins
Oct 17, 2019·Journal of Gastroenterology and Hepatology·Hirotsugu MaruyamaYasuhiro Fujiwara
May 6, 2020·Journal of Gastroenterology and Hepatology·Tiing Leong Ang

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