Aggressive invasion is observed in CD133(-)/A2B5(+) glioma-initiating cells

Oncology Letters
Ting SunZiwei DU

Abstract

Glioblastoma multiforme is the most common and fatal primary brain tumor in adults. Aggressive invasion of glioblastoma cells into brain tissue often limits complete surgical resection and contributes to therapeutic resistance. The cell surface marker, CD133, has been identified as a putative stem cell marker in normal and malignant brain tissues; CD133(-)/A2B5(+) cells exhibit neural stem-like cell properties. The invasive properties and the molecular mechanisms of CD133(-)/A2B5(+) glioma-initiating cells (GICs) were investigated in the process of self-renewal and tumorigenesis. An increased number of invasive cells through matrigel and an increase in migratory cells through filters were observed in CD133(-)/A2B5(+) GIC populations compared with matched non-initiating tumor cell populations. Considerable changes were detected in expression of mRNA and protein associated with migration or invasion. CD133(-)/A2B5(+) GIC demonstrated infiltrating growth patterns and displayed greater invasive potential under fluorescent microscopy comparing with the matched non-initiating tumor cells after cells labeled with red fluorescence protein were transplanted into the brains of athymic/nude mice. CD133(-)/A2B5(+) GICs possess strong migra...Continue Reading

References

Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Aug 27, 2005·The New England Journal of Medicine·Nader SanaiMitchel S Berger
Apr 8, 2006·Neuropathology and Applied Neurobiology·C ColinD Figarella-Branger
Oct 24, 2007·International Journal of Cancer. Journal International Du Cancer·Jian WangPer Ø Enger
Apr 3, 2008·Neurosurgery·Alfred T OgdenJeffrey N Bruce
Jun 19, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kyeung Min JooDo-Hyun Nam
Feb 27, 2009·Brain Pathology·Aurélie TchoghandjianDominique Figarella-Branger
May 12, 2009·Cell Stem Cell·Myung Jin SonHoward A Fine
May 19, 2009·Journal of Neuroscience Methods·Xuepeng ZhangMichael Chopp
May 11, 2010·Cell Stem Cell·Justin D LathiaJeremy N Rich
Feb 25, 2011·International Journal of Clinical Oncology·Norio YamamotoRobert M Hoffman
Nov 29, 2011·Cell·Peter Friedl, Stephanie Alexander
Jun 19, 2012·Cell Stem Cell·Jane E Visvader, Geoffrey J Lindeman
Jan 12, 2013·Stem Cells·Paola BresciaGiuliana Pelicci
Feb 18, 2014·Carcinogenesis·Ensieh FarahaniEmilia Wiechec
Jan 7, 2015·Journal of Cellular Biochemistry·Gianfranca MiconiBenedetta Cinque

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Citations

Oct 5, 2016·Oncology Letters·Xiaofeng WangYucheng Zhang
Nov 13, 2020·Frontiers in Cellular Neuroscience·Henry Ruiz-GarciaDaniel M Trifiletti
Feb 11, 2021·International Journal of Molecular Sciences·Cristiana AngelucciFortunata Iacopino
Mar 31, 2021·Neurosurgery Clinics of North America·Yagmur Muftuoglu, Frank Pajonk

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Methods Mentioned

BETA
surgical resection
xenografts
xenograft
enzymatic dissociation
transfection
protein assay
flow cytometry

Software Mentioned

SPSS
Launch Sensi Ansys

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