PMID: 2355136Jun 1, 1990Paper

Aggressive keratoacanthoma of the eyelid: "malignant" keratoacanthoma or squamous cell carcinoma?

The Journal of Dermatologic Surgery and Oncology
L RequenaE Sánchez Yus

Abstract

We report an aggressive keratoacanthoma of the upper eyelid that recurred at the site of a previously excised keratoacanthoma. The diagnosis was confirmed by biopsy. Because the surgery required would be extensive, medical therapy was tried first. The tumor was treated with intralesional injections of 5-fluorouracil and radiotherapy. Despite this therapy, the orbital computed tomogram showed tumor extension into the orbit, and an orbital exenteration was performed. Histopathology of the excised tumor was consistent with squamous cell carcinoma. We discuss the topic of malignant transformation of the keratoacanthoma.

Citations

Jul 18, 2003·Ophthalmology·Mark J DonaldsonRichard M Williamson
Mar 28, 2003·Cancer Genetics and Cytogenetics·Dae-Kwang KimDae-Gu Shon
Aug 1, 1994·International Journal of Dermatology·W Y WongA Guana
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Schwartz
Mar 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S C BernsteinK A Heidelberg
Aug 23, 2005·The British Journal of Ophthalmology·I LeibovitchD Selva
Mar 26, 2010·Journal of the American Academy of Dermatology·Laurie M GoodWhitney A High
Apr 16, 2005·Journal of Korean Medical Science·Tae-Won HaDae-Kwang Kim
Dec 1, 1994·Journal of Cutaneous Pathology·J P SleaterJ B Hendricks
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Related Concepts

Squamous Cell Carcinoma
Differential Diagnosis
Eyelid Diseases
Eyelid Neoplasms
Keratoacanthoma

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Carcinoma, Squamous Cell

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