Aggressive plaque modification with rotational atherectomy and/or cutting balloon before drug-eluting stent implantation for the treatment of calcified coronary lesions

Journal of Interventional Cardiology
Beatriz VaquerizoJordi Brugera

Abstract

Calcified coronary lesions may be associated with stent underexpansion, malapposition, and high rates of restenosis. The use of drug-eluting stents (DES) in such lesions has not been fully addressed in the major trials. We sought to examine the outcomes of patients who were treated with plaque modification (PM) to facilitate DES implantation. We analyzed 164 calcified coronary lesions in 145 consecutive patients who underwent aggressive PM with either rotational atherectomy (RA) and/or cutting balloon (CB) before DES implantation. CB was used in moderate calcified lesions and RA alone or followed by CB in severe calcified lesions. Patients were 68.7 +/- 10.1 years old, 47% were diabetic, 34% had left ventricular ejection fraction (LVEF) < or =50%, and 39% had 3-vessel disease. Ninety-five percent of lesions were classified as B2/C, 100% as moderately/severely calcified. PM was achieved by using CB in 57% and by RA alone or followed by CB in 43%. In 100%, a DES was implanted. There was no failure to deliver a stent. At 15 +/- 11 months follow-up, the overall major adverse cardiac events (MACE) rate was 9.6% (3.4% cardiac death, 2.3% myocardial infarction, and 3.4% target lesion revascularization [TLR]). The only independent pred...Continue Reading

References

Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Oct 1, 1996·Journal of the American College of Cardiology·G R DussaillantM B Leon
Mar 16, 2001·The American Journal of Cardiology·P L WhitlowT Feldman
Jun 2, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·R D SafianW W O'Neill
Dec 18, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·E KarvouniA Colombo
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 16, 2004·The New England Journal of Medicine·Gregg W StoneUNKNOWN TAXUS-IV Investigators
Nov 7, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Leonardo C ClavijoAugusto D Pichard
Dec 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Yukio OzakiOsamu Kato
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Mar 8, 2008·Journal of the American College of Cardiology·José M de la Torre-HernándezUNKNOWN ESTROFA Study Group
Jun 7, 2008·Journal of the American College of Cardiology·Emanuele MeligaUNKNOWN DELFT (Drug Eluting stent for LeFT main) Registry
Sep 9, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Shinichi FuruichiAntonio Colombo

❮ Previous
Next ❯

Citations

Mar 1, 2016·Expert Review of Cardiovascular Therapy·Mohamed FaragManivannan Srinivasan
Nov 9, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Glenn N LevineUNKNOWN Society for Cardiovascular Angiography and Interventions
Nov 1, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mauricio G CohenWilliam W O'Neill
Mar 24, 2015·JACC. Cardiovascular Imaging·Takashi KuboTakashi Akasaka
Feb 18, 2014·Journal of the American College of Cardiology·Mahesh V MadhavanPhilippe Généreux
Apr 7, 2015·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Paula MotaAntónio Leitão-Marques
Mar 19, 2014·JACC. Cardiovascular Interventions·Matthew I TomeySamin K Sharma
Oct 21, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Christos EftychiouJohn P Greenwood
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Jason WasiakAnneliese Spinks
Nov 12, 2019·Circulation. Cardiovascular Interventions·Adem AksoyNikos Werner
Dec 24, 2019·Interventional Cardiology·Tanush GuptaAzeem Latib
Jul 21, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Antonio Serra, Marcelo Jiménez
Aug 11, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Nileshkumar J PatelAnnapoorna S Kini
Nov 23, 2017·International Heart Journal·Yoritaka OtsukaKiyotaka Iwasaki
Feb 17, 2019·Cardiovascular Intervention and Therapeutics·Ryuichi MatsukawaHiroshi Meno
May 16, 2019·Circulation. Cardiovascular Interventions·Samin K SharmaJeffrey W Moses
Oct 26, 2016·Current Treatment Options in Cardiovascular Medicine·Paul N Fiorilli, Saif Anwaruddin
Nov 20, 2018·Journal of Biomechanical Engineering·Pengfei DongLinxia Gu
May 9, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Wei GaoJunbo Ge
Aug 26, 2021·Cardiovascular Intervention and Therapeutics·Yoshihisa KinoshitaTakahiko Suzuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.