Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis

Experimental Dermatology
Martin TeichertMoritz Felcht

Abstract

Primary cutaneous large B-cell lymphomas, leg type (PCLBCL/LT) are primary cutaneous B-cell lymphoma (PCBCL) with an intermediate prognosis. Therefore, antracycline-based polychemotherapy combined with rituximab has been recommended as first-line treatment. Yet, despite this regimen, the 5-year survival rate remains 50-66% only. Angiogenesis, the formation of a vascular network, is essential for the pathogenesis of nodal lymphomas. So far, no study has analysed angiogenesis and its key factors in PCLBCL/LT. The present study was aimed at characterizing angiogenesis in PCLBCL/LT to identify the angiogenic molecules as potential therapeutic targets. The intra-tumoral microvessel density (MVD) was assessed by immunohistochemical studies of CD20 and CD31. The MVD was higher in PCLBCL/LT compared with indolent PCBCL. Analyses of open-source microarray data showed correlation between the angiogenic molecule angiopoietin-2 (Ang-2) and pan-endothelial cell markers. ELISA studies determined a shift between Ang-2 and Ang-1 towards Ang-2 in the peripheral blood of PCLBCL/LT patients. Immunofluorescence costainings against the Ang receptor Tie2/angiogenic integrins/CD34 revealed that the vasculature in both aggressive and indolent PCBCL tu...Continue Reading

References

Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A VaccaF Dammacco
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shinji TanakaKeizo Sugimachi
Apr 26, 2003·The Journal of Investigative Dermatology·Monique N StorzSabine Kohler
Mar 19, 2004·Pathology Oncology Research : POR·Grzegorz MazurKazimierz Kuliczkowski
Nov 19, 2004·Cancer Research·Kyoko HidaMichael Klagsbrun
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Oct 15, 2005·Current Opinion in Oncology·Ad Koster, John M M Raemaekers
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher DalyJohn S Rudge
Jun 2, 2007·Circulation Research·Yvonne ReissKarl H Plate
Jul 25, 2008·Nature Reviews. Cancer·Gabriele Bergers, Douglas Hanahan
Nov 29, 2008·The New England Journal of Medicine·G LenzUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Feb 19, 2009·Molecular and Cellular Biology·Hai Tao YuanSamir M Parikh
Feb 24, 2009·Nature Reviews. Molecular Cell Biology·Hellmut G AugustinKari Alitalo
May 19, 2009·Angiogenesis·Markus Thomas, Hellmut G Augustin
Jun 4, 2010·The Journal of Biological Chemistry·Markus ThomasHellmut G Augustin
Sep 18, 2010·Leukemia & Lymphoma·Maria B KarpovaMirjana Urosevic-Maiwald
Apr 13, 2011·International Journal of Cancer. Journal International Du Cancer·Evangelos TerposUNKNOWN Greek Myeloma Study Group, Greece
Apr 25, 2012·Archives of Dermatological Research·Tomomitsu MiyagakiShinichi Sato
May 16, 2012·The Journal of Clinical Investigation·Moritz FelchtHellmut G Augustin
Mar 8, 2013·Cancer Research·Damien GeraldLaura E Benjamin
Mar 13, 2013·Neoplasia : an International Journal for Oncology Research·Domenico RibattiAngelo Vacca
Jul 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth M ChislockAnn Marie Pendergast
Jul 19, 2013·The Journal of Investigative Dermatology·Lianne KoensCornelis P Tensen
Aug 3, 2013·The Journal of Clinical Investigation·Jonathan WeltiPeter Carmeliet
Aug 21, 2013·Journal of the American Academy of Dermatology·Andrea Luísa SuárezPatricia L Myskowski

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Citations

Mar 15, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jan P NicolayCyrill Géraud
Mar 10, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Moritz FelchtWerner Kempf
Mar 29, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Moritz FelchtWerner Kempf
Apr 19, 2020·Cancer Research·Ashik Ahmed Abdul PariMoritz Felcht

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