Aggressive repeat surgery for focally recurrent primary glioblastoma: outcomes and theoretical framework

Neurosurgical Focus
Michael E SughrueCharles Teo

Abstract

OBJECT The relative benefit of repeat surgery for recurrent glioblastoma is unclear, in part due to the very heterogeneous nature of the patient population and the effect of clinician philosophy on the duration and aggressiveness of treatment. The authors sought to investigate the role of time to last recurrence on patient outcomes following aggressive repeat surgery for recurrent glioblastoma. METHODS The authors present outcomes in 104 patients undergoing repeat surgery for focally recurrent glioblastoma with at least 95% resection and adjuvant treatment at most recent prior surgery. In addition to common variables, they provide data regarding the period of progression-free survival (PFS) following an aggressive lesionectomy for focally recurrent primary glioblastoma (T2) and the time the tumor took to recur since the previous surgery (T1). They term the ratio T1/T2 the relative aggressivity index (RAI). RESULTS The median PFS was 7.8 months, 6.0 months, and 4.8 months following the second, third, and fourth-sixth craniotomies, respectively. Importantly, there was a wide range of outcomes, with time to postoperative recurrence ranging from 1 to 24 months in this group. Analysis showed no meaningful relationship between T1 and...Continue Reading

References

Jun 28, 2000·Cancer·P Kleihues, L H Sobin
Jan 4, 2008·The New England Journal of Medicine·Nader SanaiMitchel S Berger
Feb 17, 2009·Emergency Medicine Clinics of North America·J Claude Hemphill, Douglas B White
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nader Sanai, Mitchel S Berger
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Oct 16, 2010·Neurosurgery Clinics of North America·Michael E Sughrue, Charles Teo

❮ Previous
Next ❯

Citations

Jan 27, 2016·Clinical Neurology and Neurosurgery·Nicola MontemurroRiccardo Vannozzi
Jul 11, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Joshua D BurksMichael E Sughrue
Aug 2, 2016·Journal of the Egyptian National Cancer Institute·Supriya MallickGoura K Rath
Dec 3, 2016·Arquivos de neuro-psiquiatria·Willey Gonçalves ZanovelloManoel A de Paiva
Oct 23, 2015·Clinical Neuroradiology·T HuberJ S Bauer
Feb 17, 2018·Neuro-oncology·Serah ChoiJoseph F Costello
Sep 22, 2018·Journal of Neurosurgery·Ramin A MorshedMitchel S Berger
Sep 14, 2017·Neurosurgery·Reid Hoshide, Charles Teo
Dec 5, 2017·Future Oncology·Philip A SuteraDwight E Heron
Jun 14, 2020·Neurosurgical Review·David BotrosDebraj Mukherjee
Jun 16, 2018·Brain Sciences·Francesca GrazianoDomenico Gerardo Iacopino
May 5, 2017·Neurosurgery·Joshua D BurksMichael E Sughrue
Oct 24, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A A RafaelyanE N Imyanitov
Dec 12, 2020·Critical Reviews in Oncology/hematology·Silvia ScocciantiLorenzo Livi
Jan 29, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Royce W WoodroffeJeremy D W Greenlee

❮ Previous
Next ❯

Software Mentioned

Adobe Photoshop
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
B S Mann
Current Treatment Options in Oncology
Nicolas PenelAntoine Adenis
© 2022 Meta ULC. All rights reserved