Aggressive somatotrophinomas lacking clinical symptoms: neurosurgical management

Neurosurgical Review
Mario GiordanoRudolf Fahlbusch

Abstract

We report our experience about somatotrophinomas without clinical manifestation of acromegaly having radiological- and surgical-verified invasion of the cavernous sinus. We present the clinical, radiological and hormonal status of three patients affected by invasive GH-secreting pituitary adenomas without clinical signs and symptoms of acromegaly with elevation of serum IGF-1 from a series of 142 pituitary adenomas operated in our institute with the aid of intraoperative magnetic resonance imaging (MRI). Total tumor removal was possible in two of the three cases; the patients show normal hormonal status and no recurrence at long-term follow-up. In the third case, due to the different features of the tumor, complete resection was not possible and a multimodal treatment was performed that allowed regularization of the hormonal status and control of the residual tumor. GH-secreting adenomas without clinical manifestation of acromegaly are uncommon lesions. Total microsurgical excision can be curative. However, in case of partial removal, a tailored adjuvant treatment should be considered to preserve the quality of life of the patient and avoid regrowth of the lesion. In not resectable tumors, preoperative medical treatment with so...Continue Reading

References

Jan 1, 1991·British Journal of Obstetrics and Gynaecology·R PestellF Alford
Jun 1, 1987·Journal of Neurosurgery·A KlibanskiE C Ridgway
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J TourniaireC Girod
Jan 1, 1997·Neurosurgical Review·A RiegerW Burkert
Jan 27, 2005·The Journal of Clinical Endocrinology and Metabolism·Alla A SakharovaAriel L Barkan
Nov 26, 2010·Pituitary·Anna Krzentowska-KorekAlicja Hubalewska-Dydejczyk
Apr 16, 2011·European Journal of Endocrinology·Alisha N WadePeter J Snyder
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Odelia Cooper, Shlomo Melmed
Mar 13, 2013·Cancer Investigation·Marie BatisseIgor Tauveron
Nov 23, 2013·Annales d'endocrinologie·Laura ChinezuGérald Raverot
Mar 4, 2015·Endocrinology and Metabolism Clinics of North America·Sarah E Mayson, Peter J Snyder
Aug 20, 2015·Acta Neuropathologica Communications·Christian P MiermeisterRolf Buslei
Feb 11, 2016·Endocrine Pathology·W SaegerR Buslei

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Citations

Dec 12, 2018·Minerva endocrinologica·Cristina LamasIgnacio Aranda

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