PMID: 3762169Sep 1, 1986Paper

Aggressive squamous cell carcinoma of the skin after chronic lymphocytic leukemia

Journal of Surgical Oncology
N Bridges, J J Steinberg

Abstract

We report two cases of squamous cell carcinoma (SCC) of the skin subsequent to chronic lymphocytic leukemia (CLL). Both cases had an unusually aggressive course for a nonmelanoma skin malignancy with extensive metastases in both, resulting in death in one patient. A literature review supports the likelihood of an increased incidence of SCC in patients with CLL. Though the mechanism is unknown, immunosuppression may play a central role. We urge patients with CLL to avoid exposure to direct sun. Any questionable skin lesion should be biopsied early, and completely excised if it is a tumor. The patient should also be examined thoroughly for metastatic disease via subsequent follow-up visits.

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Citations

Feb 24, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·S R BeatyR F Wagner
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·John A CarucciClark C Otley
Nov 15, 2008·Current Oncology·J WongE A Barnes
Feb 22, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Khosrow MehranyClark C Otley
Oct 1, 1996·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T R Humphreys, R Malhotra
May 10, 2007·Leukemia & Lymphoma·Ewa Robak, Tadeusz Robak
Nov 12, 2005·Skinmed·Andrew L Kaplan, Jonathan L Cook
Jan 1, 2005·Journal of the American Academy of Dermatology·Richard C NolanPeter J Heenan
Nov 29, 2005·Journal of the American Academy of Dermatology·Khosrow MehranyClark C Otley
May 8, 2002·American Journal of Hematology·Christian Rifbjerg LarsenNielsaage Tøffner Clausen
Sep 12, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·M Strojan FlezarP Strojan
Jan 1, 1993·Health Affairs·S Buka, F Earls

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