PMID: 9524095Apr 2, 1998Paper

Aggressive treatment with complete remission in primary diffuse leptomeningeal gliomatosis--a case report

Journal of Neuro-oncology
P BeauchesneB Laurent

Abstract

Primary leptomeningeal gliomatosis is rare, and the diffuse form (PLDG) is even more unusual. The following report is an example. A 17 year-old man developed a syndrome characterized by extensive basal and chronic spinal meningitis. Routine biological tests showed elevated levels of CSF proteins, and moderate mononuclear pleocytosis, with no direct evidence of neoplasia, leading to a diagnosis of chronic meningitis. A second meningeal biopsy, guided by MRI and performed in the left frontal region, led to the specific diagnosis of primary diffuse leptomeningeal gliomatosis. Treatment including ventricular and lumbar shunting, a course of cortico-spinal radiation, and three courses of an eight-drug systemic chemotherapy with intrathecal methotrexate lead to complete remission over 15 months. We believe that this is the first report of such a remission in the literature.

Citations

Nov 29, 2016·Case Reports in Neurological Medicine·Ehtasham AhmadApostolos Vrettos
Jun 11, 1999·American Journal of Clinical Oncology·A C PaulinoC R Suarez
Jul 25, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Satoshi IshigeNaokatsu Saeki
Feb 11, 2010·Journal of Neuro-oncology·Matthew K KnoxWarren P Mason
Aug 6, 2002·Neurologia Medico-chirurgica·Yasushi MotoyamaSachio Nabeshima
Jun 26, 2007·World Journal of Surgical Oncology·Antonio De TommasiPasqualino Ciappetta
May 31, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Susana NovalAlfredo Adán
Nov 23, 2019·British Journal of Neurosurgery·Samuel GatzertAmit Agarwal
Oct 13, 2006·Journal of Neuro-oncology·Shoji YomoKazuhiro Hongo
Apr 9, 2008·Arquivos de neuro-psiquiatria·André Leite GonçalvesLuiz Celso Pereira Vilanova
Sep 15, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·B CirakO Unal
Jun 28, 2005·Journal of Neuro-oncology·Enrico FranceschiLucio Crinò
Jan 13, 2009·Journal of the Neurological Sciences·Melissa W KoSteven L Galetta

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