Aggressive versus expectant management of severe preeclampsia at 28 to 32 weeks' gestation: a randomized controlled trial

American Journal of Obstetrics and Gynecology
Baha M SibaiS A Friedman

Abstract

Our purpose was to determine whether aggressive or expectant management of severe preeclampsia at 28 to 32 weeks is more beneficial to maternal and neonatal outcome. Ninety-five eligible patients were randomly assigned to either aggressive (n = 46) or expectant management (n = 49). Aggressive management patients were prepared for delivery, either by cesarean or induction, 48 hours after glucocorticoids were administered. Expectant management patients were managed with bed rest, oral antihypertensives, and intensive antenatal fetal testing. At the time of randomization there were no differences between the two groups in mean systolic blood pressure (170 +/- 9.7 vs 172 +/- 9.4 mm Hg), diastolic blood pressure (110 +/- 5.4 vs 112 +/- 4.2 mm Hg), proteinuria (3.0 +/- 2.3 vs 3.6 +/- 2.3 gm per 24 hours), and gestational age (30.4 +/- 1.6 vs 30.7 +/- 1.5 weeks) for the aggressive and expectant management groups. The average latency period in the expectant management group was 15.4 days (range 4 to 36), and this period was not affected by the amount of proteinuria at randomization. There was no eclampsia or perinatal death in either group. The two groups had similar incidences of abruptio placentae (4.1% vs 4.3%) and similar days of p...Continue Reading

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References

Oct 1, 1991·American Journal of Obstetrics and Gynecology·J R BartonB M Sibai
Mar 1, 1990·American Journal of Obstetrics and Gynecology·J R BartonW B Conover
Sep 1, 1990·American Journal of Obstetrics and Gynecology·B M SibaiM Moretti
Aug 1, 1988·American Journal of Obstetrics and Gynecology·G D WaismanA Martinotti

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Citations

Sep 12, 2000·Current Hypertension Reports·R ShearJ M Moutquin
Aug 2, 2013·Journal of Obstetrics and Gynaecology of India·M K SwamyShailaja Nageshu
Dec 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W Visser, H C Wallenburg
Apr 6, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Bettina KuschelThorsten Fischer
Apr 4, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D R HallD Grové
Oct 11, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D-C DingJ-Y Liu
Aug 29, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J T Repke, J N Robinson
May 10, 2003·Obstetrics and Gynecology·Sarah H Poggi, Alessandro Ghidini
Jul 27, 2000·Obstetrics and Gynecology·S P ChauhanJ N Martin
Jan 14, 2000·Journal of Nurse-midwifery·M A Kelley
Jul 10, 2003·Clinics in Laboratory Medicine·Deirdre J LyellLinda C Giudice
Feb 13, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M I WithagenH C Wallenburg
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A C BolteG A Dekker
Feb 21, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Paulino Vigil-De GraciaJuan Ruiz
Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·UNKNOWN GRIT Study Group
Jul 25, 1996·The New England Journal of Medicine·B M Sibai
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·D O Anumba, S C Robson
Aug 19, 1999·Clinical Obstetrics and Gynecology·E R NorwitzJ T Repke
Aug 19, 1999·Clinical Obstetrics and Gynecology·S A FriedmanB M Sibai
Aug 19, 1999·Clinical Obstetrics and Gynecology·W C Mabie
Feb 28, 2002·Clinical Obstetrics and Gynecology·P Scott Barrilleaux, James N Martin Jr
Nov 1, 2002·International Anesthesiology Clinics·Tania Haddad
Nov 5, 1999·Obstetrical & Gynecological Survey·A ManyJ B Lessing
Feb 24, 2005·Clinical Obstetrics and Gynecology·Kjersti M Aagaard-Tillery, Michael A Belfort
Apr 5, 2005·Clinical Obstetrics and Gynecology·Bassam Haddad, Baha M Sibai
Sep 30, 2003·Southern Medical Journal·Sherri A LongoGabriella Pridjian
May 14, 1999·BMJ : British Medical Journal·L A MageeP von Dadelszen
Mar 12, 2005·BMJ : British Medical Journal·Ian A Greer
Jan 1, 1997·Annual Review of Medicine·A G Witlin, B M Sibai
May 7, 2011·Journal of Pregnancy·Carl H BackesPeter J Giannone
Feb 28, 2009·BMC Pregnancy and Childbirth·Kjell HaramUlrich Abildgaard
Apr 9, 2005·Pediatric Research·Sharon E MaynardS Ananth Karumanchi
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Herman T DepypereMarc Dhont
Oct 14, 2000·Journal of Perinatal Medicine·W RathJ W Dudenhausen
May 29, 2013·Annals of African Medicine·T A Jido, I A Yakasai
Dec 7, 2013·Gynécologie, obstétrique & fertilité·T BoisraméB Langer

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