Aging affects vascular structure and function in a limb-specific manner

Journal of Applied Physiology
Steven K NishiyamaRussell S Richardson

Abstract

The limb-specific effects of aging upon vessel structure and function are not well understood. Consequently, in 12 young (26 +/- 2 yr) and 12 old (72 +/- 1 yr) healthy subjects, we utilized ultrasound Doppler to evaluate intima-media thickness (IMT), ischemic reperfusion, and flow-mediated dilation (FMD) following (5 min) suprasystolic cuff occlusion in both the arm [brachial artery (BA)] and the leg [popliteal artery (PA)]. Structural measurements, whether normalized for vessel size or not, revealed a greater IMT in both the BA and PA with age (young: BA 0.028 +/- 0.001 and PA 0.046 +/- 0.003 cm, old: BA 0.039 +/- 0.002 and PA 0.073 +/- 0.005 cm; P < 0.05). Ischemic reperfusion revealed a similar pattern as IMT in terms of limb and age-related differences. There was an age-related attenuation in both BA FMD (old: 38% smaller BA FMD compared with young) and PA FMD (old: 71% smaller PA FMD compared with young). However, when this percent change was normalized for shear rate, only the PA FMD of the old group was still significantly attenuated (old: 41% smaller PA FMD/shear rate compared with young). Together, the finding of differential structural and functional parameters in the arms and legs of healthy young people, and the som...Continue Reading

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Citations

Jun 18, 2010·European Journal of Applied Physiology·M WilsonG Whyte
Sep 28, 2010·Exercise and Sport Sciences Reviews·D Walter WrayRussell S Richardson
Jan 6, 2011·Exercise and Sport Sciences Reviews·D Walter WrayRussell S Richardson
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Dec 25, 2012·American Journal of Physiology. Heart and Circulatory Physiology·H Jonathan GrootRussell S Richardson
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